CDC45 and CEP55

Data Source:
BioGRID (two hybrid, two hybrid)

		CDC45	CEP55
Description		cell division cycle 45	centrosomal protein 55
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body	Cytoplasm Centrosome Centriole Plasma Membrane Membrane Midbody Cleavage Furrow Centriolar Satellite Intercellular Bridge Flemming Body
	Molecular Function	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Mitotic DNA Replication Preinitiation Complex Assembly	Mitotic Cytokinesis Nucleus Organization Mitotic Metaphase Plate Congression Multicellular Organism Development Regulation Of Phosphatidylinositol 3-kinase Signaling Establishment Of Protein Localization Midbody Abscission Cranial Skeletal System Development
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	High density lipoprotein cholesterol levels ( 30498476) Metabolite levels ( 23823483)
Interacting Genes		25 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1	77 interacting genes: AKAP9 ANXA11 ARHGEF15 C1orf109 C1orf216 CBY2 CCBE1 CCDC120 CCHCR1 CDC37 CDC45 CDK1 CDSN CEP57L1 COL8A1 DTNB ECSIT EIF1AD ENKD1 FAM161B FAM90A1 FBF1 FXR2 GOLGA2 GOLGA8DP HAUS1 HGS HSF2BP KANK2 KIFC3 LGALS4 LRRC23 MAPK1 MAPK1IP1L MFAP1 MIA3 MORF4L2 NDEL1 NOS3 NTAQ1 PCNT PDCD6IP PEF1 PIN1 PLEKHG6 PLK1 POLM POM121 PPP1R16B PSEN2 PSMC2 PTPN23 PWWP3A RAB3D RBM14 RBM17 RBM22 RCOR3 RNF32 SDCBP SNRPB SNW1 SS18L1 SUPT5H TCL1A TEAD4 TEX11 TEX14 TFG TP53BP2 TSG101 UBC VPS37C VPS37D WASHC1 WASHC3 ZNF48
Entrez ID		8318	55165
HPRD ID		09145	12569
Ensembl ID		ENSG00000093009	ENSG00000138180
Uniprot IDs		O75419	Q53EZ4
PDB IDs		5DGO 6XTX 6XTY	3E1R 3WUT 3WUU 3WUV
Enriched GO Terms of Interacting Partners?
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