CDC45 and MCM10

Data Source:
HPRD (in vitro)

		CDC45	MCM10
Description		cell division cycle 45	minichromosome maintenance 10 replication initiation factor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body	Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex
	Molecular Function	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding	DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Identical Protein Binding Metal Ion Binding
	Biological Process	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Mitotic DNA Replication Preinitiation Complex Assembly	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Cellular Response To DNA Damage Stimulus Cell Population Proliferation
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription	Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	Nicotine dependence symptom count ( 25555482)
Interacting Genes		25 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1	38 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KLHL40 KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 PICK1 RECQL4 TNIP1 TRIM37 UBAC1 YWHAE ZBTB43 ZBTB8A
Entrez ID		8318	55388
HPRD ID		09145	11297
Ensembl ID		ENSG00000093009	ENSG00000065328
Uniprot IDs		O75419	Q7L590
PDB IDs		5DGO 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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