CDC45 and CAMK1G

Data Source:
BioGRID (two hybrid)

		CDC45	CAMK1G
Description		cell division cycle 45	calcium/calmodulin dependent protein kinase IG
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body	Golgi Membrane Intracellular Anatomical Structure Plasma Membrane Calcium- And Calmodulin-dependent Protein Kinase Complex Neuron Projection
	Molecular Function	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding	Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding
	Biological Process	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Mitotic DNA Replication Preinitiation Complex Assembly	Peptidyl-serine Phosphorylation
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription
Drugs			SU-11652 Fostamatinib
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	Adult body size ( 32376654) Age-related cognitive decline (visuospatial skill) (slope of z-scores) ( 30954325) Amyotrophic lateral sclerosis ( 23624525) Obesity (extreme) ( 21935397)
Interacting Genes		25 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1	4 interacting genes: CDC45 KRTAP10-1 KRTAP10-8 PJA1
Entrez ID		8318	57172
HPRD ID		09145	10807
Ensembl ID		ENSG00000093009	ENSG00000008118
Uniprot IDs		O75419	Q96NX5
PDB IDs		5DGO 6XTX 6XTY	2JAM
Enriched GO Terms of Interacting Partners?
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