CDC45 and GINS4

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CDC45	GINS4
Description		cell division cycle 45	GINS complex subunit 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body	GINS Complex Nucleoplasm Cytoplasm CMG Complex
	Molecular Function	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding	Protein Binding
	Biological Process	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Mitotic DNA Replication Preinitiation Complex Assembly	Double-strand Break Repair Via Break-induced Replication Inner Cell Mass Cell Proliferation DNA Strand Elongation Involved In DNA Replication
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription	Unwinding of DNA Unwinding of DNA
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)
Interacting Genes		25 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1	17 interacting genes: BIN3 CDC45 CTNNBIP1 DMAP1 GINS1 GINS2 GINS3 KIF16B LHX8 MCM2 PBX4 POLA1 POLD1 POLE PPP1R13B SIK1 SIK1B
Entrez ID		8318	84296
HPRD ID		09145	11583
Ensembl ID		ENSG00000093009	ENSG00000147536
Uniprot IDs		O75419	Q9BRT9
PDB IDs		5DGO 6XTX 6XTY	2E9X 2EHO 2Q9Q 6XTX 6XTY
Enriched GO Terms of Interacting Partners?
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