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CEP55 and CDC37
Data Source:
BioGRID
(two hybrid)
CEP55
CDC37
Description
centrosomal protein 55
cell division cycle 37, HSP90 cochaperone
Image
GO Annotations
Cellular Component
Cytoplasm
Centrosome
Centriole
Plasma Membrane
Membrane
Midbody
Cleavage Furrow
Centriolar Satellite
Intercellular Bridge
Flemming Body
Cytoplasm
Cytosol
Extracellular Exosome
Chaperone Complex
HSP90-CDC37 Chaperone Complex
Molecular Function
Protein Binding
Identical Protein Binding
Protein Binding
Protein Kinase Regulator Activity
Kinase Binding
Protein Kinase Binding
Heat Shock Protein Binding
Unfolded Protein Binding
Chaperone Binding
Hsp90 Protein Binding
Scaffold Protein Binding
Biological Process
Mitotic Cytokinesis
Nucleus Organization
Mitotic Metaphase Plate Congression
Multicellular Organism Development
Regulation Of Phosphatidylinositol 3-kinase Signaling
Establishment Of Protein Localization
Midbody Abscission
Cranial Skeletal System Development
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Folding
Protein Targeting
Posttranscriptional Regulation Of Gene Expression
ERBB2 Signaling Pathway
Protein Stabilization
Regulation Of Interferon-gamma-mediated Signaling Pathway
Regulation Of Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Mitophagy In Response To Mitochondrial Depolarization
Pathways
Signaling by ERBB2
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Constitutive Signaling by EGFRvIII
Regulation of necroptotic cell death
Downregulation of ERBB2 signaling
RHOBTB2 GTPase cycle
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
Drugs
Diseases
GWAS
High density lipoprotein cholesterol levels (
30498476
)
Metabolite levels (
23823483
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Multiple sclerosis (
21833088
)
White blood cell count (
32888494
)
Interacting Genes
77 interacting genes:
AKAP9
ANXA11
ARHGEF15
C1orf109
C1orf216
CBY2
CCBE1
CCDC120
CCHCR1
CDC37
CDC45
CDK1
CDSN
CEP57L1
COL8A1
DTNB
ECSIT
EIF1AD
ENKD1
FAM161B
FAM90A1
FBF1
FXR2
GOLGA2
GOLGA8DP
HAUS1
HGS
HSF2BP
KANK2
KIFC3
LGALS4
LRRC23
MAPK1
MAPK1IP1L
MFAP1
MIA3
MORF4L2
NDEL1
NOS3
NTAQ1
PCNT
PDCD6IP
PEF1
PIN1
PLEKHG6
PLK1
POLM
POM121
PPP1R16B
PSEN2
PSMC2
PTPN23
PWWP3A
RAB3D
RBM14
RBM17
RBM22
RCOR3
RNF32
SDCBP
SNRPB
SNW1
SS18L1
SUPT5H
TCL1A
TEAD4
TEX11
TEX14
TFG
TP53BP2
TSG101
UBC
VPS37C
VPS37D
WASHC1
WASHC3
ZNF48
178 interacting genes:
A2M
ACTB
ACTG1
AKT1
AMOTL2
APOE
APP
AR
BEND7
BHLHB9
BLZF1
BTBD10
BTBD3
C19orf44
CAMK2A
CAMK2B
CAMK2G
CARD10
CARD9
CAVIN1
CBY2
CC2D1A
CCDC138
CCDC152
CCDC91
CCHCR1
CDC37L1
CDK2
CDK3
CDK4
CDK5
CDK6
CDK7
CEP55
CEP70
CGGBP1
CHGA
CHUK
CKS1B
CKS2
CRYM
CSNK2A1
CSNK2A2
CT45A1
CTAG1A
CTAG1B
CUTC
CYP2C9
DCTN1
DEAF1
DISC1
ECSIT
EIF2AK1
EIF2S1
ELAVL3
ENOX2
EXOSC1
FAM118A
FAM9B
FATE1
FBXL12
FBXW4
GAS7
GAS8
GCDH
GCH1
GFAP
GMCL1
GOLGA2
GOLGA6L9
GRAMD2B
GRIPAP1
HIVEP1
HOMER3
HSF2BP
HSP90AA1
IFIT5
IKBKB
IKBKE
IKBKG
IKZF3
IMMT
JRK
KATNBL1
KCTD13
KCTD9
KIFC3
KLHL2
KRT75
KRT76
LMNB2
LONP1
LOXL4
LUC7L2
LZTS1
MAD1L1
MAP3K14
MAP3K3
MDFI
MID1
MIPOL1
MRPL9
MTOR
MZT2B
NCOA5
NECAB1
NECAB2
NOS3
NR2C2
NRIP3
NT5C1A
OGA
PAICS
PDE9A
PIBF1
PNMA2
POU6F2
PPHLN1
PPP5C
PRAM1
PRDX2
PRKAR1B
PRMT1
PRMT5
PRPH
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PSMC6
PSME1
PTGES3
RABGEF1
RAD23A
RAF1
REEP6
RNF32
ROPN1
RPS15A
SAFB
SEPTIN3
SNX5
SPTBN4
SQSTM1
SRC
SRRM4
SSNA1
STAMBPL1
STIP1
STK11
STK32A
STX1A
SYCE2
SYCP3
TBK1
TCF4
THAP1
THAP7
TNFAIP1
TNIP1
TRAF2
TRAF3
TRAF5
TRIM54
UBE2I
USHBP1
WAC
ZBED1
ZBTB26
ZBTB8A
ZNF205
ZNF235
ZNF266
ZNF276
ZNF655
ZNF667
ZNF837
Entrez ID
55165
11140
HPRD ID
12569
05456
Ensembl ID
ENSG00000138180
ENSG00000105401
Uniprot IDs
Q53EZ4
A0A024R7B7
Q16543
PDB IDs
3E1R
3WUT
3WUU
3WUV
1US7
2K5B
2N5X
2NCA
2W0G
5FWK
5FWL
5FWM
5FWP
5HPE
Enriched GO Terms of Interacting Partners
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