CDC45 and TRAPPC3

Data Source:
BioGRID (two hybrid)

		CDC45	TRAPPC3
Description		cell division cycle 45	trafficking protein particle complex subunit 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol TRAPP Complex Cis-Golgi Network Membrane
	Molecular Function	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding	Protein Binding
	Biological Process	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Mitotic DNA Replication Preinitiation Complex Assembly	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport COPII Vesicle Coating
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
Drugs			Palmitic Acid Myristic acid S-palmitoyl-L-cysteine
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	Intraocular pressure ( 30054594)
Interacting Genes		25 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1	10 interacting genes: APP CDC45 LIG4 PLEKHF2 TRAPPC1 TRAPPC2 TRAPPC2B TRAPPC2L TRAPPC5 TRAPPC6A
Entrez ID		8318	27095
HPRD ID		09145	11644
Ensembl ID		ENSG00000093009	ENSG00000054116
Uniprot IDs		O75419	A0A087WWM0 A0A087WYS5 O43617
PDB IDs		5DGO 6XTX 6XTY	1SZ7 2C0J 2CFH 3KXC
Enriched GO Terms of Interacting Partners?
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