CDC45 and RAB4B

Data Source:
BioGRID (two hybrid)

		CDC45	RAB4B
Description		cell division cycle 45	RAB4B, member RAS oncogene family
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome DNA Replication Preinitiation Complex Ciliary Basal Body	Endosome Plasma Membrane Secretory Granule Membrane Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Chromatin Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding	Molecular_function GTPase Activity Protein Binding GTP Binding
	Biological Process	DNA Replication Checkpoint G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of Chromatin Silencing At Telomere Mitotic DNA Replication Preinitiation Complex Assembly	Protein Transport Regulation Of Endocytosis Rab Protein Signal Transduction Neutrophil Degranulation Glucose Import
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Activation of the pre-replicative complex G1/S-Specific Transcription	Neutrophil degranulation RAB geranylgeranylation MET receptor recycling
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	Blood protein levels ( 28240269) Carotid intima media thickness (mean) ( 31801372) Chronic obstructive pulmonary disease ( 22080838 28166215) Emphysema imaging phenotypes ( 26030696) Eosinophil percentage of white cells ( 32888494) Hematocrit ( 32888494) Hemoglobin ( 32888494) Kawasaki disease ( 22081228) Red blood cell count ( 32888494) Smoking behaviour (cigarettes smoked per day) ( 30617275)
Interacting Genes		25 interacting genes: CAMK1G CDK4 CDKN1A CDKN2A CEP55 CSK GINS4 LCK MAPK3 MCM10 MCM2 MCM3 MCM6 MCM7 ORC1 ORC2 ORC3 ORC5 ORC6 POLA1 RAB4B TOPBP1 TRAPPC3 UBC ZRANB1	9 interacting genes: BOLA2 BOLA2B CDC45 EXOC5 FAM71C RAB7A RABAC1 RABEP1 VPS52
Entrez ID		8318	53916
HPRD ID		09145	11473
Ensembl ID		ENSG00000093009	ENSG00000167578
Uniprot IDs		O75419	A0A024R0K8 P61018
PDB IDs		5DGO 6XTX 6XTY	2O52
Enriched GO Terms of Interacting Partners?
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