GET1 and CLCN7

Data Source:
BioGRID (two hybrid)

		GET1	CLCN7
Description		guided entry of tail-anchored proteins factor 1	chloride voltage-gated channel 7
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleoplasm Lysosomal Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity
	Biological Process	Tail-anchored Membrane Protein Insertion Into ER Membrane	Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Stimuli-sensing channels
Drugs
Diseases			Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS			Acute anterior uveitis in ankylosing spondylitis ( 32492107) Refractive error ( 32231278)
Interacting Genes		28 interacting genes: ABHD5 APOA2 APOL2 AQP1 CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 HMOX2 HTATIP2 ORMDL3 PLPP4 PTPN9 RASGRP3 RTP2 SERP2 SLC35E3 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42	17 interacting genes: AQP7 CD53 CREB3 GDAP1 GET1 KCNN3 LHFPL5 LMNA LYVE1 MTDH OPRM1 OSTM1 PACS1 SLC38A7 SLC66A2 TLCD4 TMEM179B
Entrez ID		7485	1186
HPRD ID		04224	04103
Ensembl ID		ENSG00000182093	ENSG00000103249
Uniprot IDs		O00258	P51798
PDB IDs		6SO5	7BXU 7JM7
Enriched GO Terms of Interacting Partners?
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