GET1 and ORMDL3

Data Source:
BioGRID (two hybrid)

		GET1	ORMDL3
Description		guided entry of tail-anchored proteins factor 1	ORMDL sphingolipid biosynthesis regulator 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Endoplasmic Reticulum Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane SPOTS Complex Specific Granule Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Tail-anchored Membrane Protein Insertion Into ER Membrane	Negative Regulation Of B Cell Apoptotic Process Ceramide Metabolic Process Sphingomyelin Biosynthetic Process Regulation Of Smooth Muscle Contraction Positive Regulation Of Autophagy Myelination Neutrophil Degranulation Motor Behavior Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Serine C-palmitoyltransferase Activity
Pathways		Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Sphingolipid de novo biosynthesis Neutrophil degranulation
Drugs
Diseases
GWAS			Adult asthma ( 30787307) Asthma ( 31959851 31619474 21150878 29273806 28461288 17611496 22561531) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Atrial fibrillation ( 30061737) Autoimmune traits (pleiotropy) ( 30572963) Bronchial hyperresponsiveness in asthma ( 27439200) Crohn's disease ( 18587394 28067908 21102463) Hematological parameters ( 19820697) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 28425483 23000144 21399635 20639880) Primary biliary cirrhosis ( 22961000) Refractive error ( 32231278) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Systemic sclerosis ( 28314753) Systemising ( 31508503) Type 1 diabetes ( 30659077 21829393 25751624 19430480) Ulcerative colitis ( 28067908 20228799 21297633) White blood cell count ( 27863252 21738480)
Interacting Genes		28 interacting genes: ABHD5 APOA2 APOL2 AQP1 CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 HMOX2 HTATIP2 ORMDL3 PLPP4 PTPN9 RASGRP3 RTP2 SERP2 SLC35E3 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42	30 interacting genes: APP AQP6 ARL13B C10orf67 CERS3 COQ8A EBP EEF1A1 ELOVL4 ERGIC3 FAM209A GET1 GPR101 GPR152 HSD17B13 KCNK5 LEPROTL1 LMNA LNX1 MTIF3 PTPN11 REEP2 RETREG3 RNF5 ROM1 SLC10A1 SLC35C2 SLC7A1 SYT2 TMEM237
Entrez ID		7485	94103
HPRD ID		04224	17803
Ensembl ID		ENSG00000182093	ENSG00000172057
Uniprot IDs		O00258	A0A024R1W6 Q8N138
PDB IDs		6SO5
Enriched GO Terms of Interacting Partners?
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