CLCN7 and OSTM1

Data Source:
HPRD (in vivo)

		CLCN7	OSTM1
Description		chloride voltage-gated channel 7	osteoclastogenesis associated transmembrane protein 1
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GO Annotations	Cellular Component	Nucleoplasm Lysosomal Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Lysosomal Membrane Cytosol Integral Component Of Membrane
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity
	Biological Process	Ion Transmembrane Transport Chloride Transmembrane Transport	Osteoclast Differentiation Ion Transmembrane Transport
Pathways		Stimuli-sensing channels	Stimuli-sensing channels
Drugs
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor	Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Refractive error ( 32231278)	Major depressive disorder ( 29187746)
Interacting Genes		17 interacting genes: AQP7 CD53 CREB3 GDAP1 GET1 KCNN3 LHFPL5 LMNA LYVE1 MTDH OPRM1 OSTM1 PACS1 SLC38A7 SLC66A2 TLCD4 TMEM179B	6 interacting genes: CLCN7 GPSM1 LIG4 RGS17 RGS19 RGS20
Entrez ID		1186	28962
HPRD ID		04103	09628
Ensembl ID		ENSG00000103249	ENSG00000081087
Uniprot IDs		P51798	Q86WC4
PDB IDs		7BXU 7JM7	7BXU 7JM7
Enriched GO Terms of Interacting Partners?
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