CLCN7 and LYVE1

Data Source:
BioGRID (two hybrid)

		CLCN7	LYVE1
Description		chloride voltage-gated channel 7	lymphatic vessel endothelial hyaluronan receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Lysosomal Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity	Transmembrane Signaling Receptor Activity Protein Binding Hyaluronic Acid Binding Signaling Receptor Activity
	Biological Process	Ion Transmembrane Transport Chloride Transmembrane Transport	Cell-matrix Adhesion Response To Wounding Anatomical Structure Morphogenesis Hyaluronan Catabolic Process
Pathways		Stimuli-sensing channels	Hyaluronan uptake and degradation
Drugs
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Refractive error ( 32231278)	Blood protein levels ( 30072576)
Interacting Genes		17 interacting genes: AQP7 CD53 CREB3 GDAP1 GET1 KCNN3 LHFPL5 LMNA LYVE1 MTDH OPRM1 OSTM1 PACS1 SLC38A7 SLC66A2 TLCD4 TMEM179B	26 interacting genes: AIG1 AQP10 CLCN7 CYSRT1 EMP3 KRT34 KRTAP10-3 KRTAP10-8 KRTAP12-3 KRTAP6-2 KRTAP9-2 NBPF19 NINJ2 NOTCH2NLA NRSN1 PDGFB PIGF SERP2 SLC30A2 SLC38A7 SLC41A2 THSD7A THSD7B UBE2J1 VEGFA YIPF6
Entrez ID		1186	10894
HPRD ID		04103	05753
Ensembl ID		ENSG00000103249	ENSG00000133800
Uniprot IDs		P51798	B2R672 Q9Y5Y7
PDB IDs		7BXU 7JM7
Enriched GO Terms of Interacting Partners?
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