CLCN7 and GET1

Data Source:
BioGRID (two hybrid)

		CLCN7	GET1
Description		chloride voltage-gated channel 7	guided entry of tail-anchored proteins factor 1
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GO Annotations	Cellular Component	Nucleoplasm Lysosomal Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity	Protein Binding
	Biological Process	Ion Transmembrane Transport Chloride Transmembrane Transport	Tail-anchored Membrane Protein Insertion Into ER Membrane
Pathways		Stimuli-sensing channels	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: AQP7 CD53 CREB3 GDAP1 GET1 KCNN3 LHFPL5 LMNA LYVE1 MTDH OPRM1 OSTM1 PACS1 SLC38A7 SLC66A2 TLCD4 TMEM179B	28 interacting genes: ABHD5 APOA2 APOL2 AQP1 CAMLG CCL4L2 CD302 CD53 CLCN7 COMT COX20 ERG28 HMOX2 HTATIP2 ORMDL3 PLPP4 PTPN9 RASGRP3 RTP2 SERP2 SLC35E3 SLC7A1 SPTSSA STX2 TECR TFRC TM4SF19 TMEM42
Entrez ID		1186	7485
HPRD ID		04103	04224
Ensembl ID		ENSG00000103249	ENSG00000182093
Uniprot IDs		P51798	O00258
PDB IDs		7BXU 7JM7	6SO5
Enriched GO Terms of Interacting Partners?
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