CLCN7 and TMEM179B

Data Source:
BioGRID (two hybrid)

		CLCN7	TMEM179B
Description		chloride voltage-gated channel 7	transmembrane protein 179B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Lysosomal Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Nucleolus Plasma Membrane Integral Component Of Membrane Nuclear Speck Secretory Granule Membrane Azurophil Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity	Protein Binding
	Biological Process	Ion Transmembrane Transport Chloride Transmembrane Transport	Neutrophil Degranulation
Pathways		Stimuli-sensing channels	Neutrophil degranulation
Drugs
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Refractive error ( 32231278)	Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		17 interacting genes: AQP7 CD53 CREB3 GDAP1 GET1 KCNN3 LHFPL5 LMNA LYVE1 MTDH OPRM1 OSTM1 PACS1 SLC38A7 SLC66A2 TLCD4 TMEM179B	47 interacting genes: ADIPOQ BTN2A2 C1QL4 C2CD2L C3orf52 CCDC167 CCL3L3 CCL4 CCL4L2 CD68 CLCA4 CLCN7 CLDN1 CLDN6 CTXN3 CYB561 DERL3 ERGIC3 FAM163A FATE1 FCER1G FXYD3 GALNT15 GKN1 GPR151 GUCA2A IGFBP5 KRTAP12-2 KTN1 LRP10 LYG1 MARCHF2 MFSD5 MFSD6 PLN SERP2 SLC1A1 SLC22A1 SLC52A1 STX8 TM4SF19 TMEM14A TMEM236 TMEM237 TMEM242 TMEM47 TRARG1
Entrez ID		1186	374395
HPRD ID		04103	14186
Ensembl ID		ENSG00000103249	ENSG00000185475
Uniprot IDs		P51798	Q7Z7N9
PDB IDs		7BXU 7JM7
Enriched GO Terms of Interacting Partners?
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