CLCN7 and KCNN3

Data Source:
BioGRID (two hybrid)

		CLCN7	KCNN3
Description		chloride voltage-gated channel 7	potassium calcium-activated channel subfamily N member 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Lysosomal Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Plasma Membrane Integral Component Of Membrane Neuron Projection Neuronal Cell Body
	Molecular Function	Voltage-gated Chloride Channel Activity Chloride Channel Activity Protein Binding ATP Binding Chloride Transmembrane Transporter Activity Antiporter Activity	Calmodulin Binding Small Conductance Calcium-activated Potassium Channel Activity
	Biological Process	Ion Transmembrane Transport Chloride Transmembrane Transport	Ion Transport Potassium Ion Transmembrane Transport
Pathways		Stimuli-sensing channels	Ca2+ activated K+ channels
Drugs			Procaine Miconazole Trimebutine
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Refractive error ( 32231278)	Alzheimer's disease in APOE e4- carriers ( 25778476) Atrial fibrillation ( 28416818 29290336 30061737 29892015 20173747 22544366) Bipolar disorder ( 31043756) Birth weight ( 31043758) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Height ( 28552196) Incident atrial fibrillation ( 28416818) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Prevalent atrial fibrillation ( 28416818) Prostate cancer ( 23535732) Squamous cell lung carcinoma ( 28604730) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		17 interacting genes: AQP7 CD53 CREB3 GDAP1 GET1 KCNN3 LHFPL5 LMNA LYVE1 MTDH OPRM1 OSTM1 PACS1 SLC38A7 SLC66A2 TLCD4 TMEM179B	7 interacting genes: APP CALM1 CLCN7 EMD ERMP1 FCER1G NAPB
Entrez ID		1186	3782
HPRD ID		04103	04283
Ensembl ID		ENSG00000103249	ENSG00000143603
Uniprot IDs		P51798	A0A087WYJ0 Q9UGI6
PDB IDs		7BXU 7JM7
Enriched GO Terms of Interacting Partners?
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