TALDO1 and PEA15

Data Source:
BioGRID (two hybrid)

		TALDO1	PEA15
Description		transaldolase 1	proliferation and apoptosis adaptor protein 15
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GO Annotations	Cellular Component	Intracellular Anatomical Structure Nucleus Cytoplasm Cytosol Extracellular Exosome	Nucleoplasm Cytosol Microtubule Associated Complex
	Molecular Function	Sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate Glyceronetransferase Activity Protein Binding Monosaccharide Binding	Protein Binding
	Biological Process	Carbohydrate Metabolic Process Xylulose Biosynthetic Process Fructose 6-phosphate Metabolic Process Pentose-phosphate Shunt Pentose-phosphate Shunt, Non-oxidative Branch Glyceraldehyde-3-phosphate Metabolic Process Interleukin-12-mediated Signaling Pathway	MAPK Cascade Activation Of MAPK Activity Apoptotic Process Carbohydrate Transport Response To Morphine Negative Regulation Of Glucose Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Insulin effects increased synthesis of Xylulose-5-Phosphate TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P Pentose phosphate pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	RAF-independent MAPK1/3 activation RAF/MAP kinase cascade
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Diseases
GWAS		Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		7 interacting genes: LSM8 PEA15 TERF1 TERF2 TERF2IP UBE3A ZHX1	40 interacting genes: ABCD4 AK9 AKT1 ATP1B3 CACYBP CAMK2G CASP8 CEP120 COPS5 DNAJB1 DYRK1A FADD HTRA2 KLHL12 L1CAM LUC7L2 MAPK1 MAPK3 MTIF3 OSBPL1A PANK4 PDE4DIP PDPK1 PGM1 PLD1 PLD2 PPP4R3A PRKCA PUS3 RAMAC RPS6KA3 RPSA RSL24D1 SNRPG SON TALDO1 TENT4B TERF2IP TJP1 TRAPPC13
Entrez ID		6888	8682
HPRD ID		03640	04579
Ensembl ID		ENSG00000177156	ENSG00000162734
Uniprot IDs		A0A140VK56 P37837	B1AKZ4 B1AKZ5 Q15121 Q96FS5
PDB IDs		1F05	4IZ5 4IZA 6P6B 6P6C
Enriched GO Terms of Interacting Partners?
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