PEA15 and PLD2

Data Source:
HPRD (in vivo)

		PEA15	PLD2
Description		proliferation and apoptosis adaptor protein 15	phospholipase D2
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Microtubule Associated Complex	Endoplasmic Reticulum Membrane Plasma Membrane Presynapse
	Molecular Function	Protein Binding	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity
	Biological Process	MAPK Cascade Activation Of MAPK Activity Apoptotic Process Carbohydrate Transport Response To Morphine Negative Regulation Of Glucose Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	Phosphatidic Acid Biosynthetic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Lipid Catabolic Process Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Inositol Lipid-mediated Signaling Cell Motility
Pathways		RAF-independent MAPK1/3 activation RAF/MAP kinase cascade	Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis
Drugs			Choline Choline salicylate
Diseases
GWAS			Sphingolipid levels ( 22359512) Systemic lupus erythematosus ( 26502338)
Interacting Genes		40 interacting genes: ABCD4 AK9 AKT1 ATP1B3 CACYBP CAMK2G CASP8 CEP120 COPS5 DNAJB1 DYRK1A FADD HTRA2 KLHL12 L1CAM LUC7L2 MAPK1 MAPK3 MTIF3 OSBPL1A PANK4 PDE4DIP PDPK1 PGM1 PLD1 PLD2 PPP4R3A PRKCA PUS3 RAMAC RPS6KA3 RPSA RSL24D1 SNRPG SON TALDO1 TENT4B TERF2IP TJP1 TRAPPC13	29 interacting genes: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A HIF1A LCK MTDH MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1 VHL
Entrez ID		8682	5338
HPRD ID		04579	03857
Ensembl ID		ENSG00000162734	ENSG00000129219
Uniprot IDs		B1AKZ4 B1AKZ5 Q15121 Q96FS5	O14939
PDB IDs		4IZ5 4IZA 6P6B 6P6C	6OHM 6OHO 6OHP 6OHQ 6OHS
Enriched GO Terms of Interacting Partners?
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