PEA15 and PUS3

Data Source:
BioGRID (two hybrid)

		PEA15	PUS3
Description		proliferation and apoptosis adaptor protein 15	pseudouridine synthase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Microtubule Associated Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	RNA Binding Pseudouridine Synthase Activity TRNA Pseudouridine Synthase Activity
	Biological Process	MAPK Cascade Activation Of MAPK Activity Apoptotic Process Carbohydrate Transport Response To Morphine Negative Regulation Of Glucose Import Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors	TRNA Modification TRNA Pseudouridine Synthesis MRNA Pseudouridine Synthesis
Pathways		RAF-independent MAPK1/3 activation RAF/MAP kinase cascade	tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		40 interacting genes: ABCD4 AK9 AKT1 ATP1B3 CACYBP CAMK2G CASP8 CEP120 COPS5 DNAJB1 DYRK1A FADD HTRA2 KLHL12 L1CAM LUC7L2 MAPK1 MAPK3 MTIF3 OSBPL1A PANK4 PDE4DIP PDPK1 PGM1 PLD1 PLD2 PPP4R3A PRKCA PUS3 RAMAC RPS6KA3 RPSA RSL24D1 SNRPG SON TALDO1 TENT4B TERF2IP TJP1 TRAPPC13	1 interacting genes: PEA15
Entrez ID		8682	83480
HPRD ID		04579	15195
Ensembl ID		ENSG00000162734	ENSG00000110060
Uniprot IDs		B1AKZ4 B1AKZ5 Q15121 Q96FS5	A0A087WY59 Q9BZE2
PDB IDs		4IZ5 4IZA 6P6B 6P6C
Enriched GO Terms of Interacting Partners?
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