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PEA15 and TERF2IP
Data Source:
BioGRID
(two hybrid)
PEA15
TERF2IP
Description
proliferation and apoptosis adaptor protein 15
TERF2 interacting protein
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Microtubule Associated Complex
Nuclear Chromosome
Chromosome, Telomeric Region
Nuclear Telomere Cap Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nuclear Body
Mre11 Complex
Shelterin Complex
Molecular Function
Protein Binding
Protein Binding
Phosphatase Binding
Telomeric DNA Binding
G-rich Strand Telomeric DNA Binding
Biological Process
MAPK Cascade
Activation Of MAPK Activity
Apoptotic Process
Carbohydrate Transport
Response To Morphine
Negative Regulation Of Glucose Import
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Telomere Maintenance
Negative Regulation Of Protein Phosphorylation
Regulation Of Transcription, DNA-templated
Telomere Maintenance Via Telomerase
Regulation Of Double-strand Break Repair Via Homologous Recombination
Telomere Maintenance Via Telomere Lengthening
Telomere Capping
Protection From Non-homologous End Joining At Telomere
Regulation Of Telomere Maintenance
Negative Regulation Of Telomere Maintenance
Positive Regulation Of Peptidyl-serine Phosphorylation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of DNA Recombination At Telomere
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Localization To Chromosome, Telomeric Region
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Protein Acetylation
Pathways
RAF-independent MAPK1/3 activation
RAF/MAP kinase cascade
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Telomere Extension By Telomerase
Polymerase switching on the C-strand of the telomere
Processive synthesis on the C-strand of the telomere
Telomere C-strand (Lagging Strand) Synthesis
Telomere C-strand synthesis initiation
Removal of the Flap Intermediate from the C-strand
DNA Damage/Telomere Stress Induced Senescence
Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Smoking status (ever vs never smokers) (
30643258
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Interacting Genes
40 interacting genes:
ABCD4
AK9
AKT1
ATP1B3
CACYBP
CAMK2G
CASP8
CEP120
COPS5
DNAJB1
DYRK1A
FADD
HTRA2
KLHL12
L1CAM
LUC7L2
MAPK1
MAPK3
MTIF3
OSBPL1A
PANK4
PDE4DIP
PDPK1
PGM1
PLD1
PLD2
PPP4R3A
PRKCA
PUS3
RAMAC
RPS6KA3
RPSA
RSL24D1
SNRPG
SON
TALDO1
TENT4B
TERF2IP
TJP1
TRAPPC13
128 interacting genes:
ADA
AIMP2
AK1
AKR1A1
AKR1B10
AKR7A3
AKT1
ANXA5
ANXA8L1
AP2B1
APEX1
ARPP21
BABAM1
BANP
BCL7B
C1orf174
C9orf78
CALML3
CHMP2B
COTL1
CPNE2
CPNE3
CRK
CRYBB1
CRYGS
CTBP1
DBNL
DDX23
DDX24
DDX39A
DHX38
DNMT3A
DPP3
ENAH
EPAS1
EPS8L1
FABP2
GAGE5
GAMT
GNMT
GPKOW
H1-1
H2AC16
H4C2
HAAO
HAGH
HDGFL3
HMGB1
HMGB3
HMGN3
HMGN4
HNRNPK
IDO1
IL1RN
LANCL2
LGALSL
MAGOHB
MCM2
MDH1
MPG
MRTO4
MT1X
MT3
NAIF1
NASP
NOL3
NPSR1
NUDT14
NUDT18
NUMA1
NXNL1
OCM2
OGFR
PABIR1
PACSIN2
PACSIN3
PAFAH1B3
PCNP
PCP4
PEA15
PGLS
PGM1
PML
PNMT
POLD1
PPM1G
PPP1R2
PPP6R3
PRDX6
PRX
PTEN
PTMA
RABIF
RAD50
RASSF5
RBBP9
RECQL4
RGMA
RIF1
RPAP1
RPP25
S100P
SBDS
SCLY
SCRN2
SET
SMARCC2
SNCG
SP100
TALDO1
TBC1D10A
TBCA
TERF2
TMSB10
TMSB4Y
TOR1AIP1
TSSC4
TWF2
UCHL1
VGLL4
WDR5
WIPI2
XAGE2
XPO1
XRCC5
XRCC6
ZNF146
ZNF414
Entrez ID
8682
54386
HPRD ID
04579
05452
Ensembl ID
ENSG00000162734
ENSG00000166848
Uniprot IDs
B1AKZ4
B1AKZ5
Q15121
Q96FS5
Q9NYB0
PDB IDs
4IZ5
4IZA
6P6B
6P6C
1FEX
3K6G
4RQI
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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