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PEA15 and FADD
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo, in vitro)
PEA15
FADD
Description
proliferation and apoptosis adaptor protein 15
Fas associated via death domain
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Microtubule Associated Complex
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Death-inducing Signaling Complex
CD95 Death-inducing Signaling Complex
Neuron Projection
Cell Body
Membrane Raft
Ripoptosome
Molecular Function
Protein Binding
Protease Binding
Death Receptor Binding
Tumor Necrosis Factor Receptor Binding
Protein Binding
Tumor Necrosis Factor Receptor Superfamily Binding
Receptor Serine/threonine Kinase Binding
Death Effector Domain Binding
Identical Protein Binding
Protein-containing Complex Binding
Caspase Binding
Biological Process
MAPK Cascade
Activation Of MAPK Activity
Apoptotic Process
Carbohydrate Transport
Response To Morphine
Negative Regulation Of Glucose Import
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Kidney Development
Positive Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Adaptive Immune Response
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cell Surface Receptor Signaling Pathway
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Viral Process
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
T Cell Differentiation In Thymus
Toll-like Receptor 3 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
TRAIL-activated Apoptotic Signaling Pathway
Positive Regulation Of Activated T Cell Proliferation
T Cell Homeostasis
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Morphine
Innate Immune Response
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Proteolysis
Positive Regulation Of Transcription By RNA Polymerase II
Behavioral Response To Cocaine
Lymph Node Development
Spleen Development
Thymus Development
Defense Response To Virus
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Negative Regulation Of Necroptotic Process
Negative Regulation Of Activation-induced Cell Death Of T Cells
Cellular Response To Mechanical Stimulus
Death-inducing Signaling Complex Assembly
Motor Neuron Apoptotic Process
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Activation Of Cysteine-type Endopeptidase Activity
Necroptotic Signaling Pathway
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Positive Regulation Of CD8-positive, Alpha-beta Cytotoxic T Cell Extravasation
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
RAF-independent MAPK1/3 activation
RAF/MAP kinase cascade
Caspase activation via Death Receptors in the presence of ligand
TRIF-mediated programmed cell death
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
Regulation of necroptotic cell death
Dimerization of procaspase-8
FasL/ CD95L signaling
TRAIL signaling
TLR3-mediated TICAM1-dependent programmed cell death
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Defective RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS
Diverticular disease (
30177863
)
Interacting Genes
40 interacting genes:
ABCD4
AK9
AKT1
ATP1B3
CACYBP
CAMK2G
CASP8
CEP120
COPS5
DNAJB1
DYRK1A
FADD
HTRA2
KLHL12
L1CAM
LUC7L2
MAPK1
MAPK3
MTIF3
OSBPL1A
PANK4
PDE4DIP
PDPK1
PGM1
PLD1
PLD2
PPP4R3A
PRKCA
PUS3
RAMAC
RPS6KA3
RPSA
RSL24D1
SNRPG
SON
TALDO1
TENT4B
TERF2IP
TJP1
TRAPPC13
54 interacting genes:
ABCA1
ANK3
ATG5
BTG1
CASP10
CASP8
CASP8AP2
CFLAR
CSNK1A1
DAP3
DAPK1
DDIT4L
DDX24
DEDD
EDA2R
FAF1
FAS
FASLG
HIPK3
IKBKG
IRAK1
LRRCC1
MBD4
MKRN1
MOB4
MYD88
NACA
NOL3
NUTM2F
PARK7
PEA15
PIDD1
PIN1
PRKCZ
PTPN13
RALBP1
RAP1A
RIPK1
RNF4
RYBP
SDCBP
STAT1
STUB1
TAB1
TCEA2
TNFRSF10A
TNFRSF10B
TRADD
TRAF2
TRIM21
UBE2I
XPO5
ZCCHC12
ZMYM5
Entrez ID
8682
8772
HPRD ID
04579
03909
Ensembl ID
ENSG00000162734
ENSG00000168040
Uniprot IDs
B1AKZ4
B1AKZ5
Q15121
Q96FS5
Q13158
PDB IDs
4IZ5
4IZA
6P6B
6P6C
1A1W
1A1Z
1E3Y
1E41
2GF5
3EZQ
3OQ9
6ACI
Enriched GO Terms of Interacting Partners
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