PELI2 and PCGF2

Data Source:
BioGRID (two hybrid)

		PELI2	PCGF2
Description		pellino E3 ubiquitin protein ligase family member 2	polycomb group ring finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	DNA Binding Protein Binding Metal Ion Binding Promoter-specific Chromatin Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Interleukin-1-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Silencing Anterior/posterior Pattern Specification Histone Acetylation Histone H2A-K119 Monoubiquitination Embryonic Skeletal System Morphogenesis Cellular Response To Hydrogen Peroxide Negative Regulation Of G0 To G1 Transition Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)
Interacting Genes		34 interacting genes: BCL10 CLEC17A CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK HYAL2 IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 LZTFL1 MDFI MEOX1 MYD88 NUP62 OR7D2 PCGF2 PICALM RABEP1 REL RMDN3 SEPTIN3 SP4 SRPK1 THAP7 TMEM79 TP53 TP63 TRIM32 UBQLN4	26 interacting genes: ABHD6 CBX2 CBX6 CCND2 CD247 CTNNAL1 GJB5 HOXC9 HSF2 LMNA PELI2 PHC1 PHC2 RBCK1 RING1 RNF2 SPDEF STX2 TRAF2 UBE2D3 UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7
Entrez ID		57161	7703
HPRD ID		17835	10621
Ensembl ID		ENSG00000139946	ENSG00000277258
Uniprot IDs		Q9H716 Q9HAT8	A0A024R1V6 P35227
PDB IDs		3EGA 3EGB
Enriched GO Terms of Interacting Partners?
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