PELI2 and LZTFL1

Data Source:
BioGRID (two hybrid)

		PELI2	LZTFL1
Description		pellino E3 ubiquitin protein ligase family member 2	leucine zipper transcription factor like 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol
	Molecular Function	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Protein Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Interleukin-1-mediated Signaling Pathway	Negative Regulation Of Protein Localization To Cilium Negative Regulation Of Protein Localization To Ciliary Membrane
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)	Acne (severe) ( 24927181) COVID-19 (critical illness vs population) ( 33307546) Eosinophil percentage of white cells ( 32888494) Methadone dose in opioid dependence ( 28115739) Multiple sclerosis ( 31604244) Severe COVID-19 infection with respiratory failure (analysis I) ( 32558485) Severe COVID-19 infection with respiratory failure (analysis II) ( 32558485)
Interacting Genes		34 interacting genes: BCL10 CLEC17A CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK HYAL2 IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 LZTFL1 MDFI MEOX1 MYD88 NUP62 OR7D2 PCGF2 PICALM RABEP1 REL RMDN3 SEPTIN3 SP4 SRPK1 THAP7 TMEM79 TP53 TP63 TRIM32 UBQLN4	10 interacting genes: EHHADH FZD5 MOB1A NTAQ1 PELI2 PICK1 PSMA1 PSMB1 SDCBP TRIM68
Entrez ID		57161	54585
HPRD ID		17835	07586
Ensembl ID		ENSG00000139946	ENSG00000163818
Uniprot IDs		Q9H716 Q9HAT8	Q9NQ48
PDB IDs		3EGA 3EGB
Enriched GO Terms of Interacting Partners?
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