PCGF2 and CBX2

Data Source:
BioGRID (pull down)

		PCGF2	CBX2
Description		polycomb group ring finger 2	chromobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex	Euchromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding Promoter-specific Chromatin Binding	DNA Binding Chromatin Binding Protein Binding Methylated Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Chromatin Silencing Anterior/posterior Pattern Specification Histone Acetylation Histone H2A-K119 Monoubiquitination Embryonic Skeletal System Morphogenesis Cellular Response To Hydrogen Peroxide Negative Regulation Of G0 To G1 Transition Negative Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Differentiation Development Of Primary Sexual Characteristics
Pathways		SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Transcriptional Regulation by E2F6	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases			46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS			Brain morphology (MOSTest) ( 32665545)
Interacting Genes		26 interacting genes: ABHD6 CBX2 CBX6 CCND2 CD247 CTNNAL1 GJB5 HOXC9 HSF2 LMNA PELI2 PHC1 PHC2 RBCK1 RING1 RNF2 SPDEF STX2 TRAF2 UBE2D3 UBE2E2 UBE2Q2 UBE2T UBE2U USP11 USP7	25 interacting genes: BOLL CYSRT1 DHX57 H3-4 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP2-4 KRTAP4-12 KRTAP4-4 MDFI MEOX2 PCGF2 PHC2 RBMY1A1 RBMY1F RBMY1J RBPMS2 RNF2 RYBP TRIM55 TRIM63
Entrez ID		7703	84733
HPRD ID		10621	14397
Ensembl ID		ENSG00000277258	ENSG00000173894
Uniprot IDs		A0A024R1V6 P35227	Q14781
PDB IDs			2D9U 3H91 5EPK
Enriched GO Terms of Interacting Partners?
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