PELI2 and FRYL

Data Source:
BioGRID (two hybrid)

		PELI2	FRYL
Description		pellino E3 ubiquitin protein ligase family member 2	FRY like transcription coactivator
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Cell Cortex Site Of Polarized Growth
	Molecular Function	Protein Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Toll Signaling Pathway Regulation Of Toll Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Interleukin-1-mediated Signaling Pathway	Cell Morphogenesis Neuron Projection Development
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Adverse response to chemotherapy (amenorrhea) in breast cancer ( 31371054) Body mass index (smoking years interaction) ( 23192594) Body mass index (ever vs never smoking interaction) ( 23192594) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) End-stage kidney disease ( 31178898) Height ( 25133637) Nickel levels ( 26025379) Telomere length ( 21460395)	Bipolar disorder ( 31043756) Height ( 31562340) Hemoglobin ( 32888494) Mean platelet volume ( 32888494) Platelet count ( 29403010) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		34 interacting genes: BCL10 CLEC17A CREB3L3 DEAF1 ERO1A FN1 FRYL HNRNPK HYAL2 IRAK1 IRAK2 IRAK4 LAMC3 LTBP3 LZTFL1 MDFI MEOX1 MYD88 NUP62 OR7D2 PCGF2 PICALM RABEP1 REL RMDN3 SEPTIN3 SP4 SRPK1 THAP7 TMEM79 TP53 TP63 TRIM32 UBQLN4	6 interacting genes: CCDC187 DISC1 HOMER3 PDCD10 PELI2 PRR35
Entrez ID		57161	285527
HPRD ID		17835	18995
Ensembl ID		ENSG00000139946	ENSG00000075539
Uniprot IDs		Q9H716 Q9HAT8	B3KXG5 O94915 Q6ZR29
PDB IDs		3EGA 3EGB
Enriched GO Terms of Interacting Partners?
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