CDK5R1 and ODF1

Data Source:
BioGRID (enzymatic study)

		CDK5R1	ODF1
Description		cyclin dependent kinase 5 regulatory subunit 1	outer dense fiber of sperm tails 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Membrane Protein Kinase 5 Complex Axon Dendrite Growth Cone Neuromuscular Junction Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Intracellular Membrane-bounded Organelle Contractile Fiber Perinuclear Region Of Cytoplasm Presynapse	Outer Dense Fiber Nucleus
	Molecular Function	Protease Binding Protein Kinase Activity Calcium Ion Binding Protein Binding Kinase Activity Protein Kinase Binding Protein Kinase Activator Activity Ionotropic Glutamate Receptor Binding Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Ephrin Receptor Binding Beta-tubulin Binding Actin Filament Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Protein Binding Protein Domain Specific Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Microtubule Cytoskeleton Organization Neuron Migration Neuron Cell-cell Adhesion G Protein-coupled Acetylcholine Receptor Signaling Pathway Axon Guidance Axonal Fasciculation Brain Development Embryo Development Ending In Birth Or Egg Hatching Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebellum Development Superior Olivary Nucleus Maturation Hippocampus Development Layer Formation In Cerebral Cortex Neuron Differentiation Negative Regulation Of Axon Extension Positive Regulation Of Microtubule Polymerization Neuron Projection Development Activation Of Protein Kinase Activity Regulation Of Actin Cytoskeleton Organization Ionotropic Glutamate Receptor Signaling Pathway Serine Phosphorylation Of STAT Protein Positive Regulation Of Neuron Apoptotic Process Regulation Of Neuron Differentiation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Ephrin Receptor Signaling Pathway Rhythmic Process Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Protein Targeting To Membrane Regulation Of Synaptic Vesicle Cycle Regulation Of Signal Transduction By P53 Class Mediator	Multicellular Organism Development Spermatogenesis Cell Differentiation
Pathways		CRMPs in Sema3A signaling CRMPs in Sema3A signaling Regulation of TP53 Activity through Phosphorylation Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NGF-stimulated transcription NGF-stimulated transcription Activated NTRK2 signals through CDK5
Drugs		Indirubin-3'-monoxime 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
Diseases
GWAS			Chronic lymphocytic leukemia ( 28165464 26956414 23770605) IgA nephropathy ( 26028593) IgM levels ( 28628107) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		31 interacting genes: ACTN1 AMPH APP BLOC1S6 CAMK2A CAPN1 CAPN2 CDK16 CDK5 CDK5RAP1 CDK5RAP2 CDK5RAP3 CDK9 CHN1 CTNNB1 HSP90AA1 KRT40 KRTAP10-3 LMTK2 MTUS2 NEDD4 NES NOTCH2NLA ODF1 PAK1 SEPTIN5 SET SIAH1 STXBP1 TSC22D4 TTBK1	16 interacting genes: BAG4 CDK5R1 HOXA1 KLC1 KRT86 KRTAP12-2 LCE1C MDFI MEOX2 MTUS2 ODF2 P4HB SPAG4 SPAG5 SYCE1L TRIP6
Entrez ID		8851	4956
HPRD ID		04586	01687
Ensembl ID		ENSG00000176749	ENSG00000155087
Uniprot IDs		Q15078 Q8N619	Q14990
PDB IDs		1H4L 1UNG 1UNH 1UNL 3O0G 6LDP 7CNG
Enriched GO Terms of Interacting Partners?
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