PNLIPRP1 and PEX12

Data Source:
BioGRID (two hybrid)

		PNLIPRP1	PEX12
Description		pancreatic lipase related protein 1	peroxisomal biogenesis factor 12
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Peroxisome Peroxisomal Membrane Integral Component Of Peroxisomal Membrane Peroxisomal Importomer Complex
	Molecular Function	Triglyceride Lipase Activity Calcium Ion Binding Protein Binding Lipase Activity	Ubiquitin-protein Transferase Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding
	Biological Process	Lipid Metabolic Process	Protein Monoubiquitination Protein Targeting To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix Protein Ubiquitination
Pathways		Digestion of dietary lipid	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Drugs
Diseases			Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Anger ( 24489884) Blood protein levels ( 30072576) Body mass index ( 26426971) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Loneliness (multivariate analysis) ( 27629369)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		42 interacting genes: AQP2 BEST2 CD79A CERS4 CPLX4 CREB3 CYB5R3 EBP FAM209A FFAR2 GDAP1 GJA8 GJB5 GPR152 GPR42 GPX8 HSD17B13 KCNJ6 LEUTX LMNA LRRC25 MCFD2 MEOX2 MUC1 NDUFAF1 NEMP1 PEX12 RETREG3 SLC10A6 SLC16A2 SLC18A1 SLC34A2 SLC35C2 SLC39A2 SLC7A1 STX1A TMEM14B TMEM237 TMEM31 TMPPE TMX2 TSPAN8	36 interacting genes: ACSL5 ADIPOQ BNIP2 BTN2A2 C5orf46 CLDN10 COL8A2 CXCL16 CYBC1 DNAJC30 ERMP1 FA2H FKBP8 FXYD6 GJB2 IER3IP1 MARCHF2 MGLL NKG7 NRM PEX10 PEX19 PEX5 PNLIPRP1 PTPN9 RBFA SEC22A SEC61G SMCO4 SRGN STX8 THSD7B TMEM11 TMEM222 TREX1 TTPA
Entrez ID		5407	5193
HPRD ID		05109	03455
Ensembl ID		ENSG00000187021	ENSG00000108733
Uniprot IDs		P54315	O00623
PDB IDs		2PPL
Enriched GO Terms of Interacting Partners?
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