PNLIPRP1 and CERS4

Data Source:
BioGRID (two hybrid)

		PNLIPRP1	CERS4
Description		pancreatic lipase related protein 1	ceramide synthase 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Triglyceride Lipase Activity Calcium Ion Binding Protein Binding Lipase Activity	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity
	Biological Process	Lipid Metabolic Process	Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process
Pathways		Digestion of dietary lipid	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Anger ( 24489884) Blood protein levels ( 30072576) Body mass index ( 26426971) Loneliness ( 27629369) Loneliness (linear analysis) ( 27629369) Loneliness (multivariate analysis) ( 27629369)	Mean reticulocyte volume ( 32888494) Metabolite levels ( 31628463) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingolipid levels ( 26068415) Sphingomyelin levels ( 31551469) Thyroid stimulating hormone levels ( 30367059 32769997) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)
Interacting Genes		42 interacting genes: AQP2 BEST2 CD79A CERS4 CPLX4 CREB3 CYB5R3 EBP FAM209A FFAR2 GDAP1 GJA8 GJB5 GPR152 GPR42 GPX8 HSD17B13 KCNJ6 LEUTX LMNA LRRC25 MCFD2 MEOX2 MUC1 NDUFAF1 NEMP1 PEX12 RETREG3 SLC10A6 SLC16A2 SLC18A1 SLC34A2 SLC35C2 SLC39A2 SLC7A1 STX1A TMEM14B TMEM237 TMEM31 TMPPE TMX2 TSPAN8	47 interacting genes: C1QL4 CCL4L2 CLEC1A COL4A5 CTXN3 CXCL16 CYB5R3 EMD FATE1 FCER1G FXYD6 FXYD6-FXYD2 GPR151 IER3IP1 IGFBP5 ITGAM JAGN1 LHFPL5 MS4A1 NAT8 NEU1 PLP2 PNLIPRP1 PTPN9 SCAMP5 SCD SERF1A SERF1B SERP2 SLC13A4 SLC29A2 SLC35A1 SLC35F6 SLC7A1 SMIM11A SMIM11B STX7 STX8 TEX264 TMEM119 TMEM176A TMEM254 TMEM72 TOMM6 TSPO2 UPK1B VAMP2
Entrez ID		5407	79603
HPRD ID		05109	13962
Ensembl ID		ENSG00000187021	ENSG00000090661
Uniprot IDs		P54315	Q53HF9 Q9HA82
PDB IDs		2PPL
Enriched GO Terms of Interacting Partners?
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