HMGN1 and IRF2

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		HMGN1	IRF2
Description		high mobility group nucleosome binding domain 1	interferon regulatory factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion
	Molecular Function	DNA Binding Chromatin Binding Nucleosomal DNA Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Transcription-coupled Nucleotide-excision Repair Chromatin Organization Positive Regulation Of DNA-templated Transcription, Elongation	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Blood Coagulation Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER	Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		LDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258)	Acute kidney injury in critical illness ( 27576016) Adverse response to drug ( 30420678) Chronic lymphocytic leukemia ( 28165464) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lewy body disease ( 25188341) Night sleep phenotypes ( 27126917) Nonsyndromic cleft lip ( 31609978)
Interacting Genes		21 interacting genes: CDC42 CHEK2 EP300 HMGN2 HPF1 IRF2 LIG4 MDM2 NFE2 PARP1 PPP1CC PRKACA PRKACG PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 YWHAZ	23 interacting genes: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 HMGB1 HMGN1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFKB1 PPP3CB PRKACA RELA SPI1 STAT1 TRIM55 TRIM63
Entrez ID		3150	3660
HPRD ID		01231	00962
Ensembl ID		ENSG00000205581	ENSG00000168310
Uniprot IDs		P05114 Q6NSG7	P14316
PDB IDs
Enriched GO Terms of Interacting Partners?
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