IRF2 and IRF2BP2

Data Source:
HPRD (two hybrid, in vivo)

		IRF2	IRF2BP2
Description		interferon regulatory factor 2	interferon regulatory factor 2 binding protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Blood Coagulation Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Immature B Cell Differentiation Regulation Of Transcription By RNA Polymerase II
Pathways		Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Acute kidney injury in critical illness ( 27576016) Adverse response to drug ( 30420678) Chronic lymphocytic leukemia ( 28165464) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lewy body disease ( 25188341) Night sleep phenotypes ( 27126917) Nonsyndromic cleft lip ( 31609978)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) Bipolar disorder ( 22688191) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 25961943 20686565) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 32203549 28334899) Life threatening arrhythmia ( 22247754) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Total cholesterol levels ( 28334899) White blood cell count (eosinophil) ( 28158719)
Interacting Genes		23 interacting genes: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 HMGB1 HMGN1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFKB1 PPP3CB PRKACA RELA SPI1 STAT1 TRIM55 TRIM63	6 interacting genes: ERBB2 ERBB3 ERBB4 IRF2 MTNR1B NFATC2
Entrez ID		3660	359948
HPRD ID		00962	17160
Ensembl ID		ENSG00000168310	ENSG00000168264
Uniprot IDs		P14316	Q7Z5L9
PDB IDs
Enriched GO Terms of Interacting Partners?
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