HMGN1 and PRKACG

Data Source:
BioGRID (enzymatic study)

		HMGN1	PRKACG
Description		high mobility group nucleosome binding domain 1	protein kinase cAMP-activated catalytic subunit gamma
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Nucleus Nucleoplasm Cytosol Ciliary Base
	Molecular Function	DNA Binding Chromatin Binding Nucleosomal DNA Binding	AMP-activated Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding Protein Kinase A Regulatory Subunit Binding
	Biological Process	Transcription-coupled Nucleotide-excision Repair Chromatin Organization Positive Regulation Of DNA-templated Transcription, Elongation	Stimulatory C-type Lectin Receptor Signaling Pathway Renal Water Homeostasis Protein Phosphorylation Spermatogenesis Blood Coagulation Male Gonad Development Protein Kinase A Signaling Activation Of Protein Kinase A Activity High-density Lipoprotein Particle Assembly Cellular Response To Glucagon Stimulus
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER	PKA-mediated phosphorylation of CREB PKA-mediated phosphorylation of key metabolic factors Triglyceride catabolism PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins VEGFA-VEGFR2 Pathway CREB1 phosphorylation through the activation of Adenylate Cyclase CREB1 phosphorylation through the activation of Adenylate Cyclase Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state CD209 (DC-SIGN) signaling MAPK6/MAPK4 signaling RET signaling HDL assembly ROBO receptors bind AKAP5 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		LDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258)	Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917)
Interacting Genes		21 interacting genes: CDC42 CHEK2 EP300 HMGN2 HPF1 IRF2 LIG4 MDM2 NFE2 PARP1 PPP1CC PRKACA PRKACG PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 YWHAZ	5 interacting genes: CDK17 CETP HMGN1 TNP1 TNP2
Entrez ID		3150	5568
HPRD ID		01231	01483
Ensembl ID		ENSG00000205581	ENSG00000165059
Uniprot IDs		P05114 Q6NSG7	P22612
PDB IDs
Enriched GO Terms of Interacting Partners?
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