IRF2 and ATG7

Data Source:
BioGRID (affinity chromatography technology, pull down)

		IRF2	ATG7
Description		interferon regulatory factor 2	autophagy related 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion	Phagophore Assembly Site Extracellular Region Cytoplasm Cytosol Axoneme Axon Secretory Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Transcription Factor Binding Atg12 Activating Enzyme Activity Atg8 Activating Enzyme Activity Protein Homodimerization Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Blood Coagulation Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Autophagosome Assembly Autophagy Of Mitochondrion Protein Lipidation C-terminal Protein Lipidation Autophagy Cellular Response To Nitrogen Starvation Aging Cellular Response To Starvation Response To Glucose Protein Transport Macroautophagy Protein Phosphopantetheinylation Positive Regulation Of Protein Modification Process Protein Modification By Small Protein Conjugation Piecemeal Microautophagy Of The Nucleus Suppression By Virus Of Host Autophagy Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Neutrophil Degranulation Late Nucleophagy Positive Regulation Of Protein Catabolic Process Rhythmic Process Defense Response To Virus Chaperone-mediated Autophagy Cellular Response To Morphine Cellular Response To Hyperoxia Positive Regulation By Symbiont Of Host Autophagy Negative Regulation Of Mitochondrial DNA Replication Response To Fluoride Negative Regulation Of Oxidative Stress-induced Neuron Death
Pathways		Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production	Macroautophagy Macroautophagy Neutrophil degranulation Signaling by BRAF and RAF fusions Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Acute kidney injury in critical illness ( 27576016) Adverse response to drug ( 30420678) Chronic lymphocytic leukemia ( 28165464) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lewy body disease ( 25188341) Night sleep phenotypes ( 27126917) Nonsyndromic cleft lip ( 31609978)	Body fat mass ( 28552196) Body size at age 10 ( 32376654) Circulating chemerin levels ( 25521368) HDL cholesterol ( 24097068 25961943) HDL cholesterol levels ( 28334899) Heel bone mineral density ( 28869591) Male-pattern baldness ( 28196072) Pulse pressure ( 30578418) Relative hand skill in reading disability ( 24068947) Small vessel stroke ( 29123153) Systolic blood pressure ( 27618447 27618452 30578418)
Interacting Genes		23 interacting genes: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 HMGB1 HMGN1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFKB1 PPP3CB PRKACA RELA SPI1 STAT1 TRIM55 TRIM63	10 interacting genes: APP ATG10 ATG12 ATG3 EEF1D GABARAP GABARAPL2 IRF2 MAP1LC3A MAP1LC3B
Entrez ID		3660	10533
HPRD ID		00962	12293
Ensembl ID		ENSG00000168310	ENSG00000197548
Uniprot IDs		P14316	B3KQM6 O95352
PDB IDs
Enriched GO Terms of Interacting Partners?
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