HMGN1 and RPS6KA3

Data Source:
HPRD (in vivo, in vitro)

		HMGN1	RPS6KA3
Description		high mobility group nucleosome binding domain 1	ribosomal protein S6 kinase A3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	DNA Binding Chromatin Binding Nucleosomal DNA Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Transcription-coupled Nucleotide-excision Repair Chromatin Organization Positive Regulation Of DNA-templated Transcription, Elongation	Skeletal System Development Toll-like Receptor Signaling Pathway Apoptotic Process Cell Cycle Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Positive Regulation Of Cell Growth Response To Lipopolysaccharide Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs			Acetylsalicylic acid Fostamatinib
Diseases			Non-syndromic X-linked mental retardation Coffin-Lowry syndrome (CLS)
GWAS		LDL cholesterol levels ( 32203549) Smoking status (ever vs never smokers) ( 30643258)	Refractive error ( 32231278)
Interacting Genes		21 interacting genes: CDC42 CHEK2 EP300 HMGN2 HPF1 IRF2 LIG4 MDM2 NFE2 PARP1 PPP1CC PRKACA PRKACG PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 YWHAZ	40 interacting genes: ATP5PF BAD BARX1 CREB1 CREBBP CTNND1 EIF3C ESR1 FBXO7 FGF2 FGFR1 FGFR3 FYN GRIN1 GRIN2D H2AX H3-4 H3C1 HMGN1 HMGN2 HTR2A ILKAP KRT18 MAGI1 MAPK1 MAPK3 MAPT MASP1 NEDD4 NFKBIA NR4A1 PDPK1 PEA15 SHANK1 SMS SRC STK11 SUMO2 TP53 YBX1
Entrez ID		3150	6197
HPRD ID		01231	02092
Ensembl ID		ENSG00000205581	ENSG00000177189
Uniprot IDs		P05114 Q6NSG7	A0A384MDW3 B1AXG1 B4DG22 B7ZB17 P51812
PDB IDs			4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6 5D9K 5D9L
Enriched GO Terms of Interacting Partners?
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