IRF2 and IRF8

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		IRF2	IRF8
Description		interferon regulatory factor 2	interferon regulatory factor 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Blood Coagulation Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Plasmacytoid Dendritic Cell Differentiation Immune System Process Regulation Of Transcription By RNA Polymerase II Phagocytosis Autophagy Immune Response Myeloid Cell Differentiation Regulation Of Type I Interferon Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-12 Production Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Transcription By RNA Polymerase II Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interferon-gamma Dendritic Cell Differentiation
Pathways		Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production	Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Acute kidney injury in critical illness ( 27576016) Adverse response to drug ( 30420678) Chronic lymphocytic leukemia ( 28165464) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lewy body disease ( 25188341) Night sleep phenotypes ( 27126917) Nonsyndromic cleft lip ( 31609978)	B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Chronic lymphocytic leukemia ( 21131588 28165464 26956414 24292274 23770605) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Diabetic retinopathy ( 21441570) Gestational age at birth (maternal effect) ( 27490719) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 23128233) Limited cutaneous systemic scleroderma ( 29293537) Lymphocyte percentage of white cells ( 32888494) Major depressive disorder ( 23857890) Monocyte count ( 23314186 28193307 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple sclerosis ( 31604244 24076602 19525953 21833088) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) PR interval ( 32439900) Primary biliary cirrhosis ( 22961000) Rheumatoid arthritis ( 30423114 22446963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 27399966 26663301 26502338 28714469 19838195) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989 21779181) Systemic sclerosis (anti-centromere-positive) ( 29293537) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Thyroid autoantibody positivity (anti-thyroglobulin (TgAb) and/or anti-thyroid peroxidase (TPOAb) levels) ( 31794020) Ulcerative colitis ( 32072174 23511034)
Interacting Genes		23 interacting genes: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 HMGB1 HMGN1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFKB1 PPP3CB PRKACA RELA SPI1 STAT1 TRIM55 TRIM63	12 interacting genes: COPS2 IRF1 IRF2 IRF6 NFKB1 RELA SMURF2 SPI1 TOP1 TRAF6 TRIM21 ZBTB17
Entrez ID		3660	3394
HPRD ID		00962	03336
Ensembl ID		ENSG00000168310	ENSG00000140968
Uniprot IDs		P14316	Q02556
PDB IDs
Enriched GO Terms of Interacting Partners?
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