PARP1 and RPS3A

Data Source:
HPRD (two hybrid, in vitro)

		PARP1	RPS3A
Description		poly(ADP-ribose) polymerase 1	ribosomal protein S3A
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nuclear Envelope Nucleoplasm Transcription Regulator Complex Nucleolus Mitochondrion Membrane Nuclear Body Protein-containing Complex Protein-DNA Complex Site Of Double-strand Break Site Of DNA Damage	Nucleus Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Cytosol Focal Adhesion Cytosolic Small Ribosomal Subunit Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	DNA Binding RNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Enzyme Binding Protein Kinase Binding Estrogen Receptor Binding Identical Protein Binding Histone Deacetylase Binding Protein N-terminus Binding NAD Binding R-SMAD Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity	RNA Binding Structural Constituent Of Ribosome Protein Binding MRNA 5'-UTR Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair Transcription By RNA Polymerase II Protein ADP-ribosylation Apoptotic Process Cellular Response To DNA Damage Stimulus Mitochondrion Organization Transforming Growth Factor Beta Receptor Signaling Pathway Response To Gamma Radiation Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of SMAD Protein Complex Assembly Protein Autoprocessing Peptidyl-serine ADP-ribosylation Peptidyl-glutamic Acid Poly-ADP-ribosylation Signal Transduction Involved In Regulation Of Gene Expression Macrophage Differentiation DNA ADP-ribosylation Mitochondrial DNA Metabolic Process Cellular Response To Insulin Stimulus Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Nucleotide-excision Repair, DNA Incision Cellular Response To Oxidative Stress Cellular Response To UV Protein Modification Process DNA Damage Response, Detection Of DNA Damage Mitochondrial DNA Repair Regulation Of DNA Methylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Catalytic Activity Positive Regulation Of Mitochondrial Depolarization Positive Regulation Of SMAD Protein Signal Transduction Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Global Genome Nucleotide-excision Repair Cellular Response To Zinc Ion Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Neuron Death Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Single Strand Break Repair Regulation Of Cellular Protein Localization Response To Aldosterone Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Cellular Response To Amyloid-beta Positive Regulation Of Myofibroblast Differentiation Positive Regulation Of Double-strand Break Repair Via Homologous Recombination ATP Generation From Poly-ADP-D-ribose Positive Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of ATP Biosynthetic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Cell Differentiation Negative Regulation Of Apoptotic Process
Pathways		POLB-Dependent Long Patch Base Excision Repair vRNA Synthesis Downregulation of SMAD2/3:SMAD4 transcriptional activity SUMOylation of DNA damage response and repair proteins HDR through MMEJ (alt-NHEJ) DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER Dual Incision in GG-NER	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Theophylline Zinc Carba-nicotinamide-adenine-dinucleotide NU1025 Nicotinamide 2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone 3-Methoxybenzamide 2-(4-Chlorophenyl)-5-Quinoxalinecarboxamide 3,4-Dihydro-5-Methyl-Isoquinolinone 2-(3'-Methoxyphenyl) Benzimidazole-4-Carboxamide 6-AMINO-BENZO[DE]ISOQUINOLINE-1,3-DIONE Veliparib A-620223 5-FLUORO-1-[4-(4-PHENYL-3,6-DIHYDROPYRIDIN-1(2H)-YL)BUTYL]QUINAZOLINE-2,4(1H,3H)-DIONE Olaparib Talazoparib Niraparib Rucaparib Iniparib Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Coronary artery disease ( 29212778) Leukocyte telomere length ( 32109421 31171785) Melanoma ( 21983785) Mild to moderate chronic kidney disease ( 31178898) Nevus count or cutaneous melanoma ( 32341527 30429480) Platelet count ( 29403010) Telomere length ( 29151059)	HDL cholesterol ( 20686565)
Interacting Genes		105 interacting genes: APTX ATM BCL2 BLID BRD7 BUB3 CASP1 CASP3 CASP7 CASP8 CD86 CDKN1A CENPA CENPB CREBBP CTCF CTSB CTSG DTX2 DUX4 E2F1 ERCC6 ERG ETS1 FOXO1 GTF2F1 GZMB GZMM H1-0 H1-1 H1-2 H1-5 H2AC18 H2BC4 H3-3A H3-4 H3C1 H4C3 HDAC1 HDAC3 HIPK2 HMGA1 HMGN1 HMGN2 HMGN4 HOXB7 HPF1 HSPA2 IKBKG IL24 KAT2B KLF5 LIG3 LZTR1 MACROH2A1 MED14 MED6 MORC2 MTA3 MYBL2 NAT10 NCL NCOA6 NEDD8 NFATC1 NFKB1 NPM1 NRF1 OVOL2 PARP2 PARP3 PCNA PIAS4 POLA1 POLA2 POU2F1 PRKDC RARA RASL10B RBM14 RELA RNF144A RNF168 RPS3A RXRA SENP1 SENP3 SIRT1 SP1 SREK1 SUMO2 SUPT16H SWAP70 TCF3 TCF4 THRSP TP53 UBE2I WRN XRCC1 XRCC5 XRCC6 ZBTB16 ZBTB9 ZNF423	18 interacting genes: ATF7IP C11orf49 CCDC50 CHN1 CREB3 DDIT3 DUX4 EDEM2 FANCC HGS HSP90AA1 NEDD4 PARP1 SAP18 SOD2 TOE1 UBE2I VDAC2
Entrez ID		142	6189
HPRD ID		01435	01606
Ensembl ID		ENSG00000143799	ENSG00000145425
Uniprot IDs		A0A024R3T8 P09874	B7Z3M5 P61247
PDB IDs		1UK0 1UK1 1WOK 2COK 2CR9 2CS2 2DMJ 2JVN 2L30 2L31 2N8A 2RCW 2RD6 2RIQ 3GJW 3GN7 3L3L 3L3M 3OD8 3ODA 3ODC 3ODE 4AV1 4DQY 4GV7 4HHY 4HHZ 4L6S 4OPX 4OQA 4OQB 4PJT 4R5W 4R6E 4RV6 4UND 4UXB 4XHU 4ZZZ 5A00 5DS3 5HA9 5KPN 5KPO 5KPP 5KPQ 5WRQ 5WRY 5WRZ 5WS0 5WS1 5WTC 5XSR 5XST 5XSU 6BHV 6GHK 6NRF 6NRG 6NRH 6NRI 6NRJ 6NTU 6VKK 6VKO 6VKQ 6XVW	4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G4S 6G4W 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBD 6YBW 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOK 6ZON 6ZP4 6ZVH 6ZVJ 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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