PAK4 and DLST

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PAK4	DLST
Description		p21 (RAC1) activated kinase 4	dihydrolipoamide S-succinyltransferase
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Adherens Junction Focal Adhesion	Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix Cytosol Membrane Centriolar Satellite Oxoglutarate Dehydrogenase Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Involved In Cell-cell Adhesion Protein Serine Kinase Activity Protein Threonine Kinase Activity	Dihydrolipoyllysine-residue Succinyltransferase Activity Protein Binding Transferase Activity, Transferring Acyl Groups
	Biological Process	Regulation Of Cell Growth Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Cell Cycle Signal Transduction Cell Migration Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Angiogenesis Dendritic Spine Development Cellular Response To Organic Cyclic Compound Cell-cell Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle 2-oxoglutarate Metabolic Process Succinyl-CoA Metabolic Process Lysine Catabolic Process Protein Phosphopantetheinylation L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Histone Succinylation
Pathways		Activation of RAC1	Glyoxylate metabolism and glycine degradation Lysine catabolism Citric acid cycle (TCA cycle)
Drugs		Fostamatinib
Diseases
GWAS			anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Eosinophil counts ( 32888494) Mood instability ( 29187730) Non-small cell lung cancer ( 23144319)
Interacting Genes		25 interacting genes: APP CDC42 DGCR6L DLST FBXO25 FGFR2 G6PD GATAD2A GRB2 H1-1 INKA1 ITGAV ITGB5 LIMK1 POT1 PPARG RAN RHOU SH3RF2 SRPK1 SRPK2 TERF1 YWHAG YWHAQ YWHAZ	16 interacting genes: ARIH2 CCDC86 DLG5 FLII NAP1L1 NDRG1 OGDH PAK4 PFN2 RUSC2 SCFD1 TUBB4B UBE2D2 UMPS ZBTB16 ZHX1
Entrez ID		10298	1743
HPRD ID		05675	00520
Ensembl ID		ENSG00000130669	ENSG00000119689
Uniprot IDs		A0A024R0J1 A0A024R0L8 O96013	A0A024R6C9 B7Z6J1 P36957
PDB IDs		2BVA 2CDZ 2J0I 2OV2 2Q0N 2X4Z 4APP 4FIE 4FIF 4FIG 4FIH 4FII 4FIJ 4JDH 4JDI 4JDJ 4JDK 4L67 4NJD 4O0V 4O0X 4O0Y 4XBR 4XBU 5BMS 5I0B 5UPK 5UPL 5VED 5VEE 5VEF 5XVA 5XVF 5XVG 5ZJW 6WLX 6WLY	6H05
Enriched GO Terms of Interacting Partners?
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