PARP3 and H1-1

Data Source:
BioGRID (enzymatic study)

		PARP3	H1-1
Description		poly(ADP-ribose) polymerase family member 3	H1.1 linker histone, cluster member
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Centriole Nuclear Body Site Of Double-strand Break Intercellular Bridge	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm
	Molecular Function	Catalytic Activity NAD+ ADP-ribosyltransferase Activity Protein Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity	Double-stranded DNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Telomere Maintenance DNA Repair Double-strand Break Repair Protein ADP-ribosylation DNA ADP-ribosylation Negative Regulation Of Isotype Switching Positive Regulation Of DNA Ligation Regulation Of Mitotic Spindle Organization Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Mono-ADP-ribosylation Negative Regulation Of Telomerase RNA Reverse Transcriptase Activity Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Nucleosome Assembly Spermatogenesis Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination
Pathways			Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs		2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one -ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Olaparib Rucaparib
Diseases
GWAS
Interacting Genes		4 interacting genes: APP H1-1 MEOX2 PARP1	52 interacting genes: AEBP2 APP CCNA1 CCNA2 CCNB1 CCND2 CCNE1 CDK1 CDK2 CDK4 CDK5 CDK6 CDK7 CDKN1B CRP CTCFL EED EHMT2 EP300 EZH2 GADD45A GZMA IRAK4 KAT2B LIMK1 LIMK2 LOX NAP1L1 NAP1L4 NASP NSD3 PAK4 PARP1 PARP3 PELP1 PRDM1 PRKCA PRKCB PRKCD PRKCE PRKCZ PRKDC PTMA RBBP4 RPS6KA5 SET SNCA SUZ12 TAF1 TERF1 TERF2IP TLK1
Entrez ID		10039	3024
HPRD ID		06370	00820
Ensembl ID		ENSG00000041880	ENSG00000124610
Uniprot IDs		A0A024R318 Q9Y6F1	Q02539
PDB IDs		2EOC 3C49 3C4H 3CE0 3FHB 4GV0 4GV2 4GV4 4L6Z 4L70 4L7L 4L7N 4L7O 4L7P 4L7R 4L7U
Enriched GO Terms of Interacting Partners?
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