SENP1 and RABGAP1

Data Source:
BioGRID (enzymatic study)

		SENP1	RABGAP1
Description		SUMO specific peptidase 1	RAB GTPase activating protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane	Centrosome Cytosol Microtubule Associated Complex
	Molecular Function	Endopeptidase Activity Protein Binding SUMO-specific Protease Activity SUMO-specific Isopeptidase Activity	GTPase Activator Activity Protein Binding Tubulin Binding Small GTPase Binding
	Biological Process	Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Sumoylation Protein Desumoylation Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Signaling Pathway	Intracellular Protein Transport Cell Cycle Regulation Of GTPase Activity Activation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		SUMO is proteolytically processed	TBC/RABGAPs
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Macular thickness ( 30535121) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30891314)	Birth weight ( 31043758) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Pulse pressure ( 27841878 30578418) Systolic blood pressure ( 27841878)
Interacting Genes		22 interacting genes: APP CAV3 GCM1 HDAC1 HIPK2 KCNK1 NACC1 PARP1 PIAS3 PIM1 PML RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28	10 interacting genes: CARM1 DISC1 GABARAPL1 MAP1LC3A RAB4A RAB6A RAB6B SENP1 SENP5 STAT3
Entrez ID		29843	23637
HPRD ID		07153	06575
Ensembl ID		ENSG00000079387	ENSG00000011454
Uniprot IDs		Q6N001 Q7Z3G1 Q9P0U3	Q9Y3P9
PDB IDs		2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ	4NC6
Enriched GO Terms of Interacting Partners?
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