SENP1 and SUMO3

Data Source:
BioGRID (enzymatic study)

		SENP1	SUMO3
Description		SUMO specific peptidase 1	small ubiquitin like modifier 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body
	Molecular Function	Endopeptidase Activity Protein Binding SUMO-specific Protease Activity SUMO-specific Isopeptidase Activity	Protein Binding Protein Tag Ubiquitin-like Protein Ligase Binding
	Biological Process	Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Sumoylation Protein Desumoylation Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Signaling Pathway	Protein Sumoylation Negative Regulation Of DNA Binding Regulation Of Protein Localization To Nucleus
Pathways		SUMO is proteolytically processed	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Macular thickness ( 30535121) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30891314)	Delirium ( 29631748)
Interacting Genes		22 interacting genes: APP CAV3 GCM1 HDAC1 HIPK2 KCNK1 NACC1 PARP1 PIAS3 PIM1 PML RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28	53 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 DAXX EGLN3 FAM221A FOS HIPK2 HOMEZ HSF1 HSF2 JUN KALRN MAPKAPK3 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1 ZBTB33 ZBTB39 ZCCHC12 ZNF496
Entrez ID		29843	6612
HPRD ID		07153	03754
Ensembl ID		ENSG00000079387	ENSG00000184900
Uniprot IDs		Q6N001 Q7Z3G1 Q9P0U3	P55854
PDB IDs		2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ	1U4A 2IO1 2MP2 6K5R 6NNQ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?