SENP1 and USP28

Data Source:
BioGRID (affinity chromatography technology, pull down)

		SENP1	USP28
Description		SUMO specific peptidase 1	ubiquitin specific peptidase 28
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane	Nucleus Nucleoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Endopeptidase Activity Protein Binding SUMO-specific Protease Activity SUMO-specific Isopeptidase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Sumoylation Protein Desumoylation Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Signaling Pathway	DNA Damage Checkpoint DNA Repair Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Ras Protein Signal Transduction Cell Population Proliferation Response To Ionizing Radiation Protein Deubiquitination Protein Phosphopantetheinylation Regulation Of Protein Stability Cellular Response To UV Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Pathways		SUMO is proteolytically processed	Ub-specific processing proteases
Drugs
Diseases
GWAS		Glycated hemoglobin levels ( 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Macular thickness ( 30535121) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30891314)	Alcohol consumption (drinks per week) ( 30643258) Low density lipoprotein cholesterol levels ( 32154731) PR interval ( 32439900)
Interacting Genes		22 interacting genes: APP CAV3 GCM1 HDAC1 HIPK2 KCNK1 NACC1 PARP1 PIAS3 PIM1 PML RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28	40 interacting genes: ATXN3L BAP1 CLSPN ESPL1 HIF1A JOSD1 KDM1A MAP3K1 MDC1 MTNR1A NSMCE2 OTUB1 OTUB2 PJA1 PLA2G2A PRKD1 RFFL SENP1 SENP8 STAM STAMBP SUMO2 TP53 TP53BP1 TRIM55 TRIM63 UBC UCHL1 UCHL3 UCHL5 USP14 USP15 USP20 USP21 USP33 USP4 USP5 USP51 USP7 USP8
Entrez ID		29843	57646
HPRD ID		07153	15632
Ensembl ID		ENSG00000079387	ENSG00000048028
Uniprot IDs		Q6N001 Q7Z3G1 Q9P0U3	B4E3L3 Q96RU2
PDB IDs		2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ	2LVA 2MUU 6H4H 6H4I 6HEH 6HEI 6HEJ 6HEK
Enriched GO Terms of Interacting Partners?
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