SENP1 and KCNK1

Data Source:
HPRD (in vivo)

		SENP1	KCNK1
Description		SUMO specific peptidase 1	potassium two pore domain channel subfamily K member 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Apical Plasma Membrane Dendrite Brush Border Membrane Potassium Channel Complex Perikaryon Intracellular Membrane-bounded Organelle Recycling Endosome Synaptic Membrane Inward Rectifier Potassium Channel Complex
	Molecular Function	Endopeptidase Activity Protein Binding SUMO-specific Protease Activity SUMO-specific Isopeptidase Activity	Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding Potassium Ion Leak Channel Activity Identical Protein Binding
	Biological Process	Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Sumoylation Protein Desumoylation Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Signaling Pathway	Potassium Ion Transport Stabilization Of Membrane Potential Response To Nicotine Sodium Ion Transmembrane Transport Regulation Of Resting Membrane Potential Cardiac Conduction Potassium Ion Transmembrane Transport
Pathways		SUMO is proteolytically processed	Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) Phase 4 - resting membrane potential
Drugs			Ibutilide Quinidine Quinidine barbiturate
Diseases
GWAS		Glycated hemoglobin levels ( 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Macular thickness ( 30535121) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30891314)	Cognitive function ( 28808816) Diabetic retinopathy ( 21441570) Periodontal microbiota ( 22699663) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		22 interacting genes: APP CAV3 GCM1 HDAC1 HIPK2 KCNK1 NACC1 PARP1 PIAS3 PIM1 PML RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28	13 interacting genes: AQP6 CDIPT CREB3 CREB3L1 ERGIC3 KRTAP10-3 LMNA SENP1 STOM TCIRG1 TMEM139 TMEM14B UBE2I
Entrez ID		29843	3775
HPRD ID		07153	03447
Ensembl ID		ENSG00000079387	ENSG00000135750
Uniprot IDs		Q6N001 Q7Z3G1 Q9P0U3	A0A024R3T2 O00180
PDB IDs		2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ	3UKM
Enriched GO Terms of Interacting Partners?
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