RABGAP1 and SENP1

Data Source:
BioGRID (enzymatic study)

		RABGAP1	SENP1
Description		RAB GTPase activating protein 1	SUMO specific peptidase 1
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GO Annotations	Cellular Component	Centrosome Cytosol Microtubule Associated Complex	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Tubulin Binding Small GTPase Binding	Endopeptidase Activity Protein Binding SUMO-specific Protease Activity SUMO-specific Isopeptidase Activity
	Biological Process	Intracellular Protein Transport Cell Cycle Regulation Of GTPase Activity Activation Of GTPase Activity Regulation Of Cilium Assembly	Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Sumoylation Protein Desumoylation Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Signaling Pathway
Pathways		TBC/RABGAPs	SUMO is proteolytically processed
Drugs
Diseases
GWAS		Birth weight ( 31043758) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Pulse pressure ( 27841878 30578418) Systolic blood pressure ( 27841878)	Glycated hemoglobin levels ( 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Macular thickness ( 30535121) Reticulocyte count ( 32888494) Rheumatoid arthritis ( 30891314)
Interacting Genes		10 interacting genes: CARM1 DISC1 GABARAPL1 MAP1LC3A RAB4A RAB6A RAB6B SENP1 SENP5 STAT3	22 interacting genes: APP CAV3 GCM1 HDAC1 HIPK2 KCNK1 NACC1 PARP1 PIAS3 PIM1 PML RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28
Entrez ID		23637	29843
HPRD ID		06575	07153
Ensembl ID		ENSG00000011454	ENSG00000079387
Uniprot IDs		Q9Y3P9	Q6N001 Q7Z3G1 Q9P0U3
PDB IDs		4NC6	2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ
Enriched GO Terms of Interacting Partners?
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