CEP70 and ERCC3

Data Source:
BioGRID (two hybrid)

		CEP70	ERCC3
Description		centrosomal protein 70	ERCC excision repair 3, TFIIH core complex helicase subunit
Image		No pdb structure
GO Annotations	Cellular Component	Centrosome Cytosol	Nucleotide-excision Repair Factor 3 Complex Transcription Factor TFIIH Core Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex Transcription Factor TFIIH Holo Complex Transcription Preinitiation Complex
	Molecular Function	Protein Binding Identical Protein Binding Gamma-tubulin Binding	DNA Binding Damaged DNA Binding Helicase Activity Protein Binding ATP Binding Protein C-terminus Binding Transcription Factor Binding ATPase Activity 3'-5' DNA Helicase Activity Protein N-terminus Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Microtubule Cytoskeleton Organization Ciliary Basal Body-plasma Membrane Docking	Nucleotide-excision Repair, DNA Duplex Unwinding DNA Topological Change DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Apoptotic Process Response To Oxidative Stress Protein Localization Response To UV Viral Process Nucleotide-excision Repair, DNA Incision Hair Cell Differentiation Positive Regulation Of Apoptotic Process Embryonic Organ Development Global Genome Nucleotide-excision Repair Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Male-pattern baldness ( 28196072)
Interacting Genes		242 interacting genes: ABT1 AGBL2 AKAP17A ARHGEF3 ARMCX1 ATP5PO ATXN7 BARD1 BAZ2B BEX2 BRD1 BRMS1 BRMS1L BRPF1 BYSL C1orf35 C7orf25 C8orf33 CARD9 CAVIN3 CBX8 CCDC187 CCDC85B CDC37 CDC73 CDCA7L CEP57L1 CFAP53 CLPB COIL CWF19L2 DAXX DAZAP2 DDX41 DDX6 DNAJB11 DNTTIP2 DVL3 EAF1 EBNA1BP2 EIF3D ELOA ELOA2 EMD EMP1 ENKD1 ERCC3 FAM118B FAM124A FAM133A FAM13C FAM161A FAM161B FAM214B FAM90A1 GADD45GIP1 GAS8 GATAD2B GCC1 GEM GLYCTK GPATCH2L GPATCH4 GPX7 GSE1 HAUS1 HDAC4 HDAC6 HIC2 HMGB4 HOXB5 HOXC8 HSPD1 IK INO80B INPP5J IPCEF1 IQCE IQUB ITPKB KANK2 KANSL1 KAT14 KAT5 KAT7 KDM1A KRI1 KRT31 LAMTOR5 LCOR LENG1 LENG8 LIN37 LNX1 MAB21L2 MAGOH MBD3 MCM10 MCRS1 MEST METTL17 MFAP1 MKRN3 MRPL44 NEBL NIPSNAP3A NKAP NKAPD1 NOL12 NOP2 NOP53 NOXA1 NRIP1 NTAQ1 NUSAP1 ODAD4 PAM16 PIBF1 PIMREG PKN1 PLA2G2A PPFIA1 PPIG PPP1R16B PPP1R18 PRKRIP1 PRPF18 PRPF3 PRPF31 PSMA1 PSORS1C2 RASSF10 RBM10 RCOR3 RHPN1 RNF169 RNF6 RPL13 SCNM1 SEC14L1 SERPINH1 SETD5 SFR1 SH2D4A SLU7 SMARCE1 SNRPD2 SNW1 SOD2 SPANXN3 SRGN SSX3 STK25 STMN2 SUV39H1 SUV39H2 SYT17 SYTL4 SYTL5 TAF1D TBC1D22B TBC1D30 TCAF1 TCEANC TEAD4 TLK2 TRAF3IP3 TRIM29 TRIM3 TRIM42 TSFM TSGA10IP TSHZ3 TTLL10 TXLNB TXN2 USP2 UTP11 UTP14A UTP14C UTP25 UTP3 VXN WT1 YJU2 ZBTB16 ZBTB24 ZBTB4 ZBTB47 ZBTB48 ZBTB49 ZBTB8A ZCCHC10 ZFC3H1 ZFHX3 ZFP1 ZFP91 ZGPAT ZNF136 ZNF140 ZNF148 ZNF165 ZNF169 ZNF17 ZNF20 ZNF202 ZNF227 ZNF239 ZNF264 ZNF266 ZNF302 ZNF329 ZNF35 ZNF366 ZNF408 ZNF410 ZNF417 ZNF426 ZNF433 ZNF439 ZNF490 ZNF491 ZNF555 ZNF557 ZNF572 ZNF574 ZNF578 ZNF587 ZNF599 ZNF607 ZNF648 ZNF669 ZNF688 ZNF696 ZNF775 ZNF777 ZNF785 ZNF835 ZNF860 ZSCAN12 ZSCAN21 ZSCAN23	37 interacting genes: ADAMTSL4 AR BCR BLZF1 CCNC CCNH CDC42 CDK7 CDK8 CEP70 CEP76 E2F1 ERCC2 GOLGA2 GTF2E1 GTF2E2 GTF2H1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 KPNA3 MAGED1 MCF2 MNAT1 MSANTD2 PSMC5 RAD52 ROPN1 SNW1 SRPK2 TP53 TRIM14 TRIM27 XIAP XPC ZSCAN1
Entrez ID		80321	2071
HPRD ID		16779	00593
Ensembl ID		ENSG00000114107	ENSG00000163161
Uniprot IDs		A0A140VJG2 B7Z2D2 Q8NHQ1	B3KRG2 B3KTH1 G3V1S1 P19447
PDB IDs			4ERN 5IVW 5IY6 5IY7 5IY8 5IY9 5OF4 6NMI 6O9L 6O9M 6RO4
Enriched GO Terms of Interacting Partners?
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