SH2B2 and INSR

Number of citations of the paper that reports this interaction (PubMedID 10196204)
30

Data Source:
HPRD (in vitro)

		SH2B2	INSR
Description		SH2B adaptor protein 2	insulin receptor
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Nuclear Envelope Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Insulin Receptor Complex Caveola External Side Of Plasma Membrane Endosome Membrane Membrane Axon Nuclear Lumen Dendrite Membrane Neuronal Cell Body Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding	Amyloid-beta Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin-activated Receptor Activity Insulin-like Growth Factor Receptor Binding Protein Binding ATP Binding GTP Binding Protein Domain Specific Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Cargo Receptor Activity Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding Protein-containing Complex Binding PTB Domain Binding
	Biological Process	Signal Transduction Blood Coagulation Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway	Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Internalization Heart Morphogenesis Carbohydrate Metabolic Process Regulation Of Transcription, DNA-templated Protein Phosphorylation Receptor-mediated Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Learning Memory Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Epidermis Development Male Gonad Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Transformation Of Host Cell By Virus Male Sex Determination Adrenal Gland Development Positive Regulation Of Cell Migration Exocrine Pancreas Development Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Cellular Response To Insulin Stimulus Positive Regulation Of Kinase Activity Peptidyl-tyrosine Autophosphorylation Glucose Homeostasis Positive Regulation Of Protein Complex Disassembly Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Regulation Of Embryonic Development Positive Regulation Of Glucose Import Protein Autophosphorylation Positive Regulation Of Developmental Growth Anatomical Structure Development Positive Regulation Of Meiotic Cell Cycle Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Respiratory Burst Cellular Response To Growth Factor Stimulus Dendritic Spine Maintenance Amyloid-beta Clearance Neuron Projection Maintenance Regulation Of Female Gonad Development
Pathways		Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling
Drugs			Insulin Human Insulin Lispro Insulin Glargine Insulin Pork Mecasermin Insulin Aspart Insulin Detemir Insulin Glulisine Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate NN344 AT1391 [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID Chromic chloride Insulin Degludec Brigatinib
Diseases			Rabson-Mendenhall syndrome Leprechaunism ; Donohue syndrome
GWAS		Type 2 diabetes ( 31049640)	Asthma (childhood onset) ( 27142222) Birth weight ( 31043758) Blood urea nitrogen levels ( 31152163) Diabetic retinopathy ( 21441570) Diastolic blood pressure ( 27841878 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diffusing capacity of carbon monoxide ( 30694715) Diverticular disease ( 30177863) HDL cholesterol ( 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 20881960 25282103 31562340) Hip circumference adjusted for BMI ( 28552196 25673412) Hypertension ( 31879980) Hypothyroidism ( 27182965 22493691) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Perceived unattractiveness to mosquitoes ( 28199695) Polycystic ovary syndrome ( 22885925) Pulse pressure ( 27618448 30578418) Serum uric acid levels ( 30993211) Systolic blood pressure ( 28135244 27841878 28739976 27618448 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Thyroid hormone levels ( 23408906) Triglyceride levels ( 28334899) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 30275531) Type 2 diabetes ( 30297969) Urate levels ( 31578528 23263486)
Interacting Genes		22 interacting genes: AKT1 ASB6 BTK CBL EPOR ERBB2 FYN GRB2 INSR JAK1 JAK2 JAK3 KIT LYN MTDH NTRK1 NTRK2 PDLIM7 SH2B1 SHC1 SORBS1 SYK	86 interacting genes: ACP1 ADRB2 AHSG ARF1 ARHGAP26 CALM1 CALM2 CALM3 CAV1 CAV3 CBL CCDC88A CEACAM1 CRK CRKL CSK DOK1 DOK4 DOK5 DUSP18 DUSP19 ENPP1 ERBB2 FABP4 FRS2 GAB1 GRB10 GRB14 GRB7 HRAS IGF1R IGF2 INS INSRR IRF7 IRS1 IRS2 JAK1 JAK2 KHDRBS1 KRT27 KRT31 MAD2L1 MAPK3 MARCHF1 PIK3R1 PIK3R3 PLCG1 PRKCA PRKCD PTK2 PTPN1 PTPN11 PTPN12 PTPN2 PTPN6 PTPRC PTPRF PTPRR RACK1 RAF1 RASA1 SH2B1 SH2B2 SHC1 SMAD2 SNX1 SNX2 SNX4 SNX6 SOCS1 SOCS2 SOCS3 SOCS6 SORBS1 SRC STAT5A STAT5B STUB1 STYX SYNCRIP TEAD1 TRIM72 VAV1 VAV3 YWHAB
Entrez ID		10603	3643
HPRD ID		16097	00975
Ensembl ID		ENSG00000160999	ENSG00000171105
Uniprot IDs		O14492	P06213
PDB IDs		1Q2H	1GAG 1I44 1IR3 1IRK 1P14 1RQQ 2AUH 2B4S 2HR7 2MFR 2Z8C 3BU3 3BU5 3BU6 3EKK 3EKN 3ETA 3W11 3W12 3W13 4IBM 4OGA 4XLV 4XSS 4XST 4ZXB 5E1S 5HHW 5J3H 5KQV 5U1M 6HN4 6HN5 6PXV 6PXW 6SOF
Enriched GO Terms of Interacting Partners?
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