SH2B2 and SH2B1

Number of citations of the paper that reports this interaction (PubMedID 15767667)
26

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		SH2B2	SH2B1
Description		SH2B adaptor protein 2	SH2B adaptor protein 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Nucleus Cytosol Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity Protein Binding
	Biological Process	Signal Transduction Blood Coagulation Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Lamellipodium Assembly Intracellular Signal Transduction Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of SMAD Protein Signal Transduction Regulation Of DNA Biosynthetic Process
Pathways		Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Type 2 diabetes ( 31049640)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat percentage ( 26833246) Body mass index ( 19079260 19079261 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Crohn's disease ( 28067908 21102463) Dental caries (decayed, missing and filled teeth) ( 31533690) Educational attainment ( 25201988) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) General risk tolerance (MTAG) ( 30643258) Hand grip strength ( 29691431) Inflammatory bowel disease ( 28067908) Intelligence ( 28530673) Mean corpuscular volume ( 27863252) Obesity ( 23563607) QT interval ( 29213071) Red blood cell count ( 27863252) Waist circumference ( 25673412) Weight ( 19079260)
Interacting Genes		22 interacting genes: AKT1 ASB6 BTK CBL EPOR ERBB2 FYN GRB2 INSR JAK1 JAK2 JAK3 KIT LYN MTDH NTRK1 NTRK2 PDLIM7 SH2B1 SHC1 SORBS1 SYK	13 interacting genes: CSAD EGFR FGFR3 FRS3 GRB2 IGF1R INSR JAK2 KIAA0319 NTRK1 NTRK2 RHBG SH2B2
Entrez ID		10603	25970
HPRD ID		16097	12336
Ensembl ID		ENSG00000160999	ENSG00000178188
Uniprot IDs		O14492	A0A024QZ92 A0A024QZC2 A0A024QZD2 B3KNV5 B4DLN5 Q9NRF2
PDB IDs		1Q2H	5W3R
Enriched GO Terms of Interacting Partners?
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