SH2B2 and JAK1

Number of citations of the paper that reports this interaction (PubMedID 11751854)
23

Data Source:
HPRD (in vivo)

		SH2B2	JAK1
Description		SH2B adaptor protein 2	Janus kinase 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Nucleus Cytoplasm Endosome Cytosol Cytoskeleton Focal Adhesion Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Growth Hormone Receptor Binding Protein Binding ATP Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding
	Biological Process	Signal Transduction Blood Coagulation Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway	MAPK Cascade Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Intracellular Signal Transduction Interleukin-12-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Interleukin-21-mediated Signaling Pathway Response To Antibiotic Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Interleukin-35-mediated Signaling Pathway Positive Regulation Of Sprouting Angiogenesis
Pathways		Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production	Interleukin-6 signaling Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation ISG15 antiviral mechanism Interleukin-7 signaling Interleukin-7 signaling Other interleukin signaling RAF/MAP kinase cascade Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-35 Signalling Interleukin-9 signaling Interleukin-2 signaling Interleukin-12 signaling Interleukin-12 signaling Interleukin-27 signaling Interleukin-27 signaling Interleukin-21 signaling Interferon alpha/beta signaling Interleukin receptor SHC signaling Regulation of IFNA signaling Regulation of IFNA signaling
Drugs			Myricetin 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE Ruxolitinib Tofacitinib Baricitinib
Diseases
GWAS		Type 2 diabetes ( 31049640)	Core binding factor acute myeloid leukemia ( 27903959) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Plasma anti-thyroglobulin levels ( 29678681) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		22 interacting genes: AKT1 ASB6 BTK CBL EPOR ERBB2 FYN GRB2 INSR JAK1 JAK2 JAK3 KIT LYN MTDH NTRK1 NTRK2 PDLIM7 SH2B1 SHC1 SORBS1 SYK	71 interacting genes: ABL1 BRCA1 BTK CCR1 CCR5 CSF2RB CSF3R CXCR4 EIF2AK2 ELP2 ERBB2 FER FES GAB1 GHR GRB2 H3-4 IFNAR2 IFNGR1 IGF1R IL10RA IL21R IL2RB IL2RG IL3RA IL4R IL5RA IL6ST IL7R IL9R INPP5D INSR IRS1 IRS2 JAK3 JAKMIP1 MDK OSMR PDGFRA PDGFRB PIK3R1 PLA2G4A PLAUR PLCG2 PRKCZ PRMT5 PTK2B PTPN11 PTPN2 PTPN6 PTPRC RACK1 RAF1 SH2B2 SHB SOCS1 SOCS3 STAM STAM2 STAT1 STAT2 STAT3 STAT5A STAT6 SYK TEC TNFRSF1A TOP1 TSHR TYK2 USP6
Entrez ID		10603	3716
HPRD ID		16097	00992
Ensembl ID		ENSG00000160999	ENSG00000162434
Uniprot IDs		O14492	P23458 Q6P669
PDB IDs		1Q2H	3EYG 3EYH 4E4L 4E4N 4E5W 4EHZ 4EI4 4FK6 4GS0 4I5C 4IVB 4IVC 4IVD 4K6Z 4K77 4L00 4L01 5E1E 5HX8 5IXD 5IXI 5KHW 5KHX 5L04 5WO4 6AAH 6BBU 6C7Y 6DBN 6ELR 6GGH 6HZU 6N77 6N78 6N79 6N7A 6N7B 6N7C 6N7D
Enriched GO Terms of Interacting Partners?
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