ATRIP and PRKDC

Number of citations of the paper that reports this interaction (PubMedID 15758953)
446

Data Source:
BioGRID (pull down)

		ATRIP	PRKDC
Description		ATR interacting protein	protein kinase, DNA-activated, catalytic subunit
Image
GO Annotations	Cellular Component	Nucleoplasm	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Protein-containing Complex Protein-DNA Complex Nonhomologous End Joining Complex
	Molecular Function	Protein Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Double-stranded DNA Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Enzyme Binding Protein Domain Specific Binding
	Biological Process	DNA Damage Checkpoint DNA Replication DNA Repair Interstrand Cross-link Repair Regulation Of Signal Transduction By P53 Class Mediator	Telomere Maintenance Somitogenesis Negative Regulation Of Protein Phosphorylation Activation Of Innate Immune Response B Cell Lineage Commitment Pro-B Cell Differentiation T Cell Lineage Commitment Negative Regulation Of Immunoglobulin Production Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cellular Protein Modification Process Protein Phosphorylation Cellular Response To DNA Damage Stimulus Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Response To Activity Telomere Capping Protein Ubiquitination Peptidyl-serine Phosphorylation Protein Destabilization Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Ectopic Germ Cell Programmed Cell Death Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Rhythmic Process Spleen Development Thymus Development Positive Regulation Of Developmental Growth Regulation Of Smooth Muscle Cell Proliferation Regulation Of Epithelial Cell Proliferation Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Double-strand Break Repair Via Alternative Nonhomologous End Joining Negative Regulation Of Cellular Senescence Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Response To Gamma Radiation
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) E3 ubiquitin ligases ubiquitinate target proteins
Drugs			Caffeine SF1126
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908)
Interacting Genes		21 interacting genes: BRCA1 C1orf94 CCDC28B CDC23 CDC6 CDK16 CEP164 CINP FAAP100 FAM156A LNX1 METTL21A MID2 MOS MX2 POLR1C PRKDC RPA3 SCG2 SPRY2 TASOR2	89 interacting genes: ABL1 AICDA AKT1 AKT2 AP1B1 ATM ATRIP BRCA1 C1D CASP3 CCNB1 CHEK1 CHEK2 CHUK CIB1 CLK1 CTDP1 DCAF1 DCLRE1C E4F1 EIF2S2 EIF4EBP1 EP300 ERG FH GSK3A GSK3B GZMB H1-1 H1-2 H2AX HDAC3 HMGB1 HMGB2 HNRNPA1 HNRNPC HOXC4 HSF1 HSP90AA1 IKBKB ILF2 JUN KAT2A LIG4 LYN MAPK8 MBP MKNK1 MRE11 MTNR1B NBN NCF1 NCF2 NCF4 NCOA6 NR3C1 PARP1 PCNA PDX1 PGR POU2F1 PPP6C PPP6R1 PPP6R3 PRKCD RAD17 RASSF1 RBBP8 RPA1 RPA2 SGO1 SP1 SRF SUMO2 THRA THRB TOP1 TP53 TREX1 UBE2I USF1 WRN XPA XRCC4 XRCC5 XRCC6 YWHAG YWHAQ ZBTB7A
Entrez ID		84126	5591
HPRD ID			02941
Ensembl ID		ENSG00000164053	ENSG00000253729
Uniprot IDs		A0A024R2U4 A0A024R307 Q8WXE1	P78527
PDB IDs		4IGK 4NB3 5YZ0	5LUQ 5W1R 5Y3R
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?