PRKDC and E4F1

Number of citations of the paper that reports this interaction (PubMedID 10608806)
247

Data Source:
BioGRID (unspecified method)

		PRKDC	E4F1
Description		protein kinase, DNA-activated, catalytic subunit	E4F transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Transcription Factor Complex Nucleolus Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Protein-containing Complex Protein-DNA Complex Nonhomologous End Joining Complex	Nucleoplasm Cytoplasm Spindle
	Molecular Function	Double-stranded DNA Binding RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Enzyme Binding Protein Domain Specific Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transferase Activity CAMP Response Element Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Somitogenesis Negative Regulation Of Protein Phosphorylation Activation Of Innate Immune Response B Cell Lineage Commitment Pro-B Cell Differentiation T Cell Lineage Commitment Negative Regulation Of Immunoglobulin Production Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cellular Protein Modification Process Protein Phosphorylation Cellular Response To DNA Damage Stimulus Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Response To Activity Telomere Capping Protein Ubiquitination Peptidyl-serine Phosphorylation Protein Destabilization Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Ectopic Germ Cell Programmed Cell Death Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fibroblast Proliferation Rhythmic Process Spleen Development Thymus Development Positive Regulation Of Developmental Growth Regulation Of Smooth Muscle Cell Proliferation Regulation Of Epithelial Cell Proliferation Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Double-strand Break Repair Via Alternative Nonhomologous End Joining Negative Regulation Of Cellular Senescence Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Response To Gamma Radiation	Negative Regulation Of Transcription By RNA Polymerase II DNA Replication Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Cell Cycle Process Viral Process Protein Ubiquitination Regulation Of Growth Cell Division Mitotic Cell Cycle Arrest Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) E3 ubiquitin ligases ubiquitinate target proteins
Drugs		Caffeine SF1126
Diseases
GWAS
Interacting Genes		89 interacting genes: ABL1 AICDA AKT1 AKT2 AP1B1 ATM ATRIP BRCA1 C1D CASP3 CCNB1 CHEK1 CHEK2 CHUK CIB1 CLK1 CTDP1 DCAF1 DCLRE1C E4F1 EIF2S2 EIF4EBP1 EP300 ERG FH GSK3A GSK3B GZMB H1-1 H1-2 H2AX HDAC3 HMGB1 HMGB2 HNRNPA1 HNRNPC HOXC4 HSF1 HSP90AA1 IKBKB ILF2 JUN KAT2A LIG4 LYN MAPK8 MBP MKNK1 MRE11 MTNR1B NBN NCF1 NCF2 NCF4 NCOA6 NR3C1 PARP1 PCNA PDX1 PGR POU2F1 PPP6C PPP6R1 PPP6R3 PRKCD RAD17 RASSF1 RBBP8 RPA1 RPA2 SGO1 SP1 SRF SUMO2 THRA THRB TOP1 TP53 TREX1 UBE2I USF1 WRN XPA XRCC4 XRCC5 XRCC6 YWHAG YWHAQ ZBTB7A	14 interacting genes: ANP32A ATM ATR CDKN2A EHMT2 HMGA2 KRTAP10-4 KRTAP10-7 PRKDC RASSF1 RB1 SMAD9 TP53 UPF2
Entrez ID		5591	1877
HPRD ID		02941	04317
Ensembl ID		ENSG00000253729	ENSG00000167967
Uniprot IDs		P78527	Q66K89
PDB IDs		5LUQ 5W1R 5Y3R
Enriched GO Terms of Interacting Partners?
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