UCHL3 and TRIM55

Number of citations of the paper that reports this interaction (PubMedID 22626734)
5

Data Source:
BioGRID (enzymatic study)

		UCHL3	TRIM55
Description		ubiquitin C-terminal hydrolase L3	tripartite motif containing 55
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nucleus Cytoplasm Microtubule
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity NEDD8-specific Protease Activity Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding	Protein Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Catabolic Process Post-translational Protein Modification	Signal Transduction
Pathways		UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483)	Coronary heart disease event reduction (statin therapy interaction) ( 22666496) Metabolite levels ( 23823483) Recurrent major depressive disorder ( 29317602)
Interacting Genes		19 interacting genes: ATM ATXN7L3 CDH1 LONRF1 NEDD8 NSG2 PJA1 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBE2S USP15 USP21 USP28 XRCC5	62 interacting genes: ACTA1 ANKRD1 ATP5F1B ATXN3 ATXN3L BRAP CKM DCAF6 DES EEF1G EHHADH EIF3E ESPL1 FHL2 FLNA FLNB FLNC GFM1 GMEB1 LMCD1 MDM4 MRPL19 MRPL41 MYBPC1 MYBPC3 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 OTUB1 OTUB2 PCGF1 PIAS1 PIAS2 PIAS3 RNF114 SQSTM1 STAM TCAP TNNI1 TNNI2 TNNI3 TRIM27 TRIM54 TRIM63 TTN UBE2D1 UBE2D2 UBE2D3 UBE2L3 UCHL3 UCHL5 USP13 USP28 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		7347	84675
HPRD ID		04367	05927
Ensembl ID		ENSG00000118939	ENSG00000147573
Uniprot IDs		A0A087WTB8 A0A140VJZ4 P15374	Q9BYV6
PDB IDs		1UCH 1XD3 6ISU
Enriched GO Terms of Interacting Partners?
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