UCHL3 and UBE2S

Number of citations of the paper that reports this interaction (PubMedID 20622874)
119

Data Source:
BioGRID (enzymatic study)

		UCHL3	UBE2S
Description		ubiquitin C-terminal hydrolase L3	ubiquitin conjugating enzyme E2 S
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Cell Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity NEDD8-specific Protease Activity Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Anaphase-promoting Complex Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Catabolic Process Post-translational Protein Modification	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Cell Division Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483)
Interacting Genes		19 interacting genes: ATM ATXN7L3 CDH1 LONRF1 NEDD8 NSG2 PJA1 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBE2S USP15 USP21 USP28 XRCC5	40 interacting genes: AKT1 ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CTNNB1 CYLD FBXO5 FZR1 GMNN HERC1 LINC00839 MDM2 OTUB1 OTUD7B PRKN PTEN RBCK1 RNF7 STAMBP UBA1 UBA6 UBB UBC UCHL3 USP15 USP2 USP21 USP5 USP7 ZRANB1
Entrez ID		7347	27338
HPRD ID		04367	15603
Ensembl ID		ENSG00000118939	ENSG00000108106
Uniprot IDs		A0A087WTB8 A0A140VJZ4 P15374	Q16763
PDB IDs		1UCH 1XD3 6ISU	1ZDN 5BNB 5L9T 6QH3 6QHK
Enriched GO Terms of Interacting Partners?
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