ICAM5 and PSEN2

Number of citations of the paper that reports this interaction (PubMedID 11719200)
57

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		ICAM5	PSEN2
Description		intercellular adhesion molecule 5	presenilin 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Golgi Membrane Kinetochore Nucleus Nuclear Inner Membrane Mitochondrial Inner Membrane Lysosomal Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Synaptic Vesicle Cell Surface Membrane Apical Plasma Membrane Z Disc Axon Growth Cone Neuromuscular Junction Protein-containing Complex Ciliary Rootlet Neuronal Cell Body Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Integral Component Of Presynaptic Membrane
	Molecular Function	Integrin Binding Protein Binding	Endopeptidase Activity Protein Binding Aspartic Endopeptidase Activity, Intramembrane Cleaving
	Biological Process	Phagocytosis Cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response Cell-cell Adhesion	Response To Hypoxia Membrane Protein Ectodomain Proteolysis Calcium Ion Transport Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Notch Receptor Processing, Ligand-dependent Intracellular Signal Transduction Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Ephrin Receptor Signaling Pathway Amyloid-beta Metabolic Process Regulation Of Calcium Import Into The Mitochondrion Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions	Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3
Drugs
Diseases			Alzheimer's disease (AD)
GWAS		Blood protein levels ( 30072576 29875488 28240269) Inflammatory skin disease ( 25574825) Lymphocyte percentage of white cells ( 27863252) White blood cell count ( 27863252)	Heel bone mineral density ( 30598549)
Interacting Genes		5 interacting genes: ACTN1 ITGAL ITGB2 PSEN1 PSEN2	61 interacting genes: AAMP ACTG1 AP1G1 APH1A APH1B APP AURKA BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HLA-DMB HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OGA PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1
Entrez ID		7087	5664
HPRD ID		03509	02860
Ensembl ID		ENSG00000105376	ENSG00000143801
Uniprot IDs		Q8N6I2 Q9UMF0	P49810
PDB IDs		3BN3 4OI9 4OIA 4OIB
Enriched GO Terms of Interacting Partners?
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