ICAM5 and ITGAL

Number of citations of the paper that reports this interaction (PubMedID 8995416)
13

Data Source:
HPRD (in vitro)

		ICAM5	ITGAL
Description		intercellular adhesion molecule 5	integrin subunit alpha L
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Plasma Membrane Integrin Complex Cell Surface Membrane Integrin AlphaL-beta2 Complex Specific Granule Membrane Extracellular Exosome
	Molecular Function	Integrin Binding Protein Binding	Protein Binding ICAM-3 Receptor Activity Protein-containing Complex Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Phagocytosis Cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response Cell-cell Adhesion	T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Phagocytosis Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Signal Transduction Integrin-mediated Signaling Pathway Extracellular Matrix Organization Memory T Cell Extravasation Receptor Clustering Neutrophil Degranulation Regulation Of Immune Response Leukocyte Migration Cell-cell Adhesion
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Integrin cell surface interactions Neutrophil degranulation RUNX3 Regulates Immune Response and Cell Migration
Drugs			Efalizumab Antithymocyte immunoglobulin (rabbit) Lovastatin Simvastatin 1-Acetyl-4-(4-{4-[(2-Ethoxyphenyl)Thio]-3-Nitrophenyl}Pyridin-2-Yl)Piperazine LFA703 (S)-2-((S)-3-ISOBUTYL-2,5-DIOXO-4-QUINOLIN-3-YLMETHYL-[1,4]DIAZEPAN-1YL)-N-METHYL-3-NAPHTALEN-2-YL-PROPIONAMIDE 7A-[(4-cyanophenyl)methyl]-6-(3,5-dichlorophenyl)-5-oxo-2,3,5,7A-tetrahydro-1H-pyrrolo[1,2-A]pyrrole-7-carbonitrile 3-({4-[(1E)-3-morpholin-4-yl-3-oxoprop-1-en-1-yl]-2,3-bis(trifluoromethyl)phenyl}sulfanyl)aniline Lifitegrast
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Inflammatory skin disease ( 25574825) Lymphocyte percentage of white cells ( 27863252) White blood cell count ( 27863252)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil percentage of white cells ( 27863252) Smooth-surface caries ( 24556642) Ulcerative colitis ( 28067908 23128233) White blood cell count ( 27863252)
Interacting Genes		5 interacting genes: ACTN1 ITGAL ITGB2 PSEN1 PSEN2	7 interacting genes: F11R ICAM1 ICAM3 ICAM5 PTPRC RANBP9 SHARPIN
Entrez ID		7087	3683
HPRD ID		03509	01079
Ensembl ID		ENSG00000105376	ENSG00000005844
Uniprot IDs		Q8N6I2 Q9UMF0	B2RAL6 P20701
PDB IDs		3BN3 4OI9 4OIA 4OIB	1CQP 1DGQ 1IJ4 1LFA 1MJN 1MQ8 1MQ9 1MQA 1RD4 1T0P 1XDD 1XDG 1XUO 1ZON 1ZOO 1ZOP 2ICA 2K8O 2M3E 2O7N 3BN3 3BQM 3BQN 3E2M 3EOA 3EOB 3F74 3F78 3HI6 3M6F 3TCX 4IXD 5E6R 5E6S 5E6U 6BXB 6BXF 6BXJ 6CKB
Enriched GO Terms of Interacting Partners?
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